製品名Furosemide, Na+/2Cl-/K+ cotransporter inhibitor
製品の詳細Inhibitor of the Na+/2Cl-/K+ cotransporter. Also GABAA antagonist.
生理活性の詳細Inhibitor of the Na+/2Cl-/K+ cotransporter. Loop diuretic. Also acts as a non-competitive antagonist at GABAA receptors displaying approx. 100-fold greater selectivity for α6-containing receptors over α1-containing receptors.
保存方法Store at Room Temperature. The product can be stored for up to 12 months.
溶解性Soluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Receptors & Transporters
- Ion pumps / transporter
- Na+/2Cl-/K+ cotransporter
This product has been referenced in:
- Guyon A et al. Furosemide modulation of GABA(A) receptors in dopaminergic neurones of the rat substantia nigra. Neuropharmacology 43:750-63 (2002). Read more (PubMed: 12367620) »
- Thompson SA et al. Residues in transmembrane domains I and II determine gamma-aminobutyric acid type AA receptor subtype-selective antagonism by furosemide. Mol Pharmacol 55:993-9 (1999). Read more (PubMed: 10347239) »
- Romano G et al. The site of action of furosemide. Pharmacol Res 37:409-19 (1998). Read more (PubMed: 9642037) »