Key features and details
- Mouse monoclonal [LK26] to Folate Binding Protein/FBP
- Suitable for: IHC-Fr, IP
- Reacts with: Human
- Isotype: IgG2a
製品名Anti-Folate Binding Protein/FBP antibody [LK26]
Folate Binding Protein/FBP 一次抗体 製品一覧
製品の詳細Mouse monoclonal [LK26] to Folate Binding Protein/FBP
アプリケーション適用あり: IHC-Fr, IPmore details
Tissue, cells or virus corresponding to Folate Binding Protein/FBP. Gestational choriocarcinoma cell line, Lu-75.
- Frozen Placenta or Ovarian Carcinoma (Negative control: Mouse serum or IgG1 isotype-matched negative control antibody, diluted to the same concentration as the primary antibody, should also be included in each run.)
Previously labelled as Folate Binding Protein
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
バッファーPreservative: 0.1% Sodium azide
Constituents: 1% BSA, PBS
Concentration information loading...
Our Abpromise guarantee covers the use of ab3361 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IP||Use at an assay dependent concentration.|
機能Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
組織特異性Exclusively expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum.
関連疾患Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]. NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Note=Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function.
配列類似性Belongs to the folate receptor family.
翻訳後修飾Eight disulfide bonds are present.
The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
細胞内局在Cell membrane. Secreted.
- Information by UniProt
- adult antibody
- Adult folate binding protein antibody
- Adult folate-binding protein antibody
ab3361 は 10 報の論文で使用されています。
- Chen J & Li L Aberrant Expression of Folate Metabolism Enzymes and Its Diagnosis and Survival Prediction in Ovarian Carcinoma. Anal Cell Pathol (Amst) 2019:1438628 (2019). PubMed: 31049278
- Tesarova B et al. Folic acid-mediated re-shuttling of ferritin receptor specificity towards a selective delivery of highly cytotoxic nickel(II) coordination compounds. Int J Biol Macromol 126:1099-1111 (2018). PubMed: 30605747
- Siwowska K et al. Folate Receptor-Positive Gynecological Cancer Cells: In Vitro and In Vivo Characterization. Pharmaceuticals (Basel) 10:N/A (2017). PubMed: 28809784
- Oseledchyk A et al. Folate-Targeted Surface-Enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detection of Microscopic Ovarian Cancer. ACS Nano 11:1488-1497 (2017). PubMed: 27992724
- Xie M et al. Expression of folate receptors in nasopharyngeal and laryngeal carcinoma and folate receptor-mediated endocytosis by molecular targeted nanomedicine. Int J Nanomedicine 8:2443-51 (2013). Human . PubMed: 23874095
- Roger E et al. Folic Acid Functionalized Nanoparticles for Enhanced Oral Drug Delivery. Mol Pharm : (2012). Flow Cyt . PubMed: 22670575
- Chen WT et al. Dynamic contrast-enhanced folate-receptor-targeted MR imaging using a Gd-loaded PEG-dendrimer-folate conjugate in a mouse xenograft tumor model. Mol Imaging Biol 12:145-54 (2010). ICC/IF ; Human . PubMed: 19636639
- Chen H et al. Folate-mediated intracellular drug delivery increases the anticancer efficacy of nanoparticulate formulation of arsenic trioxide. Mol Cancer Ther 8:1955-63 (2009). Flow Cyt ; Human . PubMed: 19567824
- Zhang K et al. Receptor-mediated delivery of siRNAs by tethered nucleic acid base-paired interactions. RNA 14:577-83 (2008). PubMed: 18218703
- Gravier J et al. Improvement of meta-tetra(hydroxyphenyl)chlorin-like photosensitizer selectivity with folate-based targeted delivery. synthesis and in vivo delivery studies. J Med Chem 51:3867-77 (2008). WB ; Human . PubMed: 18553957