Key features and details
- Rabbit polyclonal to FLAP
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Rat
- Isotype: IgG
FLAP 一次抗体 製品一覧
製品の詳細Rabbit polyclonal to FLAP
アプリケーション適用あり: WB, IHC-Pmore details
種交差性交差種: Mouse, Rat
Recombinant fragment within Human FLAP. The exact sequence is proprietary. Center region.
Database link: P20292
- WB: Rat spleen tissue. IHC-P: Mouse intestine and ovary tissue.
保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)
Concentration information loading...
精製度Immunogen affinity purified
Our Abpromise guarantee covers the use of ab272870 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000.|
|IHC-P||1/100 - 1/1000. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.|
機能Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
関連疾患Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition.
配列類似性Belongs to the MAPEG family.
ドメインThe C-terminal part after residue 140 is mostly unstructured.
細胞内局在Nucleus membrane. Endoplasmic reticulum membrane.
- Information by UniProt
- 5-lipoxygenase activating protein antibody
- AL5AP_HUMAN antibody
- ALOX 5AP antibody
Anti-FLAP antibody (ab272870) at 1/500 dilution + Rat spleen tissue at 50 µg
Paraffin-embedded mouse intestine tissue stained for FLAP using ab272870 at a 1/500 dilution in immunohistochemical analysis. Antigen retrieval using EDTA based, pH 8.0 buffer, 15 minutes.
Paraffin-embedded mouse ovary tissue stained for FLAP using ab272870 at a 1/500 dilution in immunohistochemical analysis. Antigen retrieval using EDTA based, pH 8.0 buffer, 15 minutes.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.