Key features and details
- FITC Chicken polyclonal to Fibrinogen
- Reacts with: Rat, Rabbit, Human, Pig
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgY
製品名FITC Anti-Fibrinogen antibody
Fibrinogen 一次抗体 製品一覧
製品の詳細FITC Chicken polyclonal to Fibrinogen
標識FITC. Ex: 493nm, Em: 528nm
種交差性交差種: Rat, Rabbit, Human, Pig
Purified full length human Fibrinogen.
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保存方法Shipped at 4°C. Store at +4°C.
Preservative: 0.1% Sodium azide
Constituents: 0.87% Sodium chloride, 0.328% Sodium phosphate
Concentration information loading...
特記事項（精製）The IgY fraction is isolated by a two step PEG precipitation procedure followed by ammonium sulphate precipitation.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
機能Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
関連疾患Defects in FGA are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. This is a rare autosomal recessive disorder characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Note=The majority of cases of afibrinogenemia are due to truncating mutations. Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha-dysfibrinogenemias.
Defects in FGA are a cause of amyloidosis type 8 (AMYL8) [MIM:105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.
配列類似性Contains 1 fibrinogen C-terminal domain.
ドメインA long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
翻訳後修飾The alpha chain is not glycosylated.
Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers.
About one-third of the alpha chains in the molecules in blood were found to be phosphorylated.
Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
Phosphorylation sites are present in the extracellular medium.
- Information by UniProt
- FGA antibody
- FGB antibody
- FGG antibody
ab73925 は 1 報の論文で使用されています。
- Verhaegen C et al. Early thrombogenicity of coronary stents: comparison of bioresorbable polymer sirolimus-eluting and bare metal stents in an aortic rat model. Am J Cardiovasc Dis 10:72-83 (2020). PubMed: 32685265