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FITC Anti-CD18 抗体 [MEM-48], prediluted (ab18238)

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Flow Cytometry - FITC Anti-CD18 antibody [MEM-48], prediluted (ab18238)

    Key features and details

    • FITC Mouse monoclonal [MEM-48] to CD18, prediluted
    • Suitable for: Flow Cyt
    • Reacts with: Human
    • Conjugation: FITC. Ex: 493nm, Em: 528nm
    • Isotype: IgG1

    Conjugates logo Related conjugates and formulations

    Carrier Free Unconjugated

    製品の概要

    • 製品名

      FITC Anti-CD18 antibody [MEM-48], prediluted
      CD18 一次抗体 製品一覧

    • 製品の詳細

      FITC Mouse monoclonal [MEM-48] to CD18, prediluted

    • 由来種

      Mouse

    • 標識

      FITC. Ex: 493nm, Em: 528nm

    • アプリケーション

      適用あり: Flow Cytmore details

    • 種交差性

      交差種: Human

    • 免疫原

      Tissue, cells or virus corresponding to Human CD18. Leucocytes of a patient suffering from a LGL-type leukaemia

    • エピトープ

      The antibody recognizes an epitope involving residues 534-546 in cysteine-rich repeat 3 of the CD18 antigen.

    • 特記事項

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    製品の特性

    アプリケーション

    The Abpromise guarantee

    Abpromise保証は、 次のテスト済みアプリケーションにおけるab18238の使用に適用されます

    アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

    アプリケーション Abreviews 特記事項
    Flow Cyt
    Use 0.75µl for 106 cells.

    ab91356 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

     
    特記事項
    Flow Cyt
    Use 0.75µl for 106 cells.

    ab91356 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

     

    ターゲット情報

    • 機能

      Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.

    • 関連疾患

      Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.

    • 配列類似性

      Belongs to the integrin beta chain family.
      Contains 1 VWFA domain.

    • 翻訳後修飾

      Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins.

    • 細胞内局在

      Membrane.
    • Information by UniProt

    • 参照データベース

      • 別名

        • 95 subunit beta antibody
        • Beta 2 (antigen CD18 (p95) antibody
        • CD 18 antibody
        • CD18 antibody
        • Cell surface adhesion glycoprotein LFA 1/CR3/P150,959 beta subunit precursor) antibody
        • Cell surface adhesion glycoproteins LFA 1/CR3/p150,95 subunit beta antibody
        • Cell surface adhesion glycoproteins LFA-1/CR3/p150 antibody
        • Complement component 3 receptor 3 and 4 subunit antibody
        • Complement receptor C3 beta subunit antibody
        • Complement receptor C3 subunit beta antibody
        • Integrin beta 2 antibody
        • Integrin beta chain beta 2 antibody
        • Integrin beta-2 (ITGB2) antibody
        • Integrin beta-2 antibody
        • Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) antibody
        • ITB2_HUMAN antibody
        • ITGB2 antibody
        • LAD antibody
        • LCAMB antibody
        • Leukocyte associated antigens CD18/11A, CD18/11B, CD18/11C antibody
        • Leukocyte cell adhesion molecule CD18 antibody
        • LFA 1 antibody
        • LFA1 antibody
        • Lymphocyte function associated antigen 1 (LFA1) antibody
        • Lymphocyte function associated antigen 1 antibody
        • MAC 1 antibody
        • MAC1 antibody
        • Macrophage antigen 1 (mac1) beta antibody
        • MF17 antibody
        • MFI7 antibody
        • OTTHUMP00000115278 antibody
        • OTTHUMP00000115279 antibody
        • OTTHUMP00000115280 antibody
        • OTTHUMP00000115281 antibody
        • OTTHUMP00000115282 antibody
        see all

      画像

      • Flow Cytometry - FITC Anti-CD18 antibody [MEM-48], prediluted (ab18238)
        Flow Cytometry - FITC Anti-CD18 antibody [MEM-48], prediluted (ab18238)
        Overlay histogram showing peripheral blood lymphocytes stained with ab18238 (red line). The cells incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab18238, 0.5 µg/1x106 cells) for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 FITC (2 µg/1x106 cells ) for 30 min at 22°C. Acquisition of >5,000 events was performed.

      参考文献 (1)

      ab18238 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

      ab18238 は 1 報の論文で使用されています。

      • Yu T  et al. Affinity, lateral mobility, and clustering contribute independently to beta 2-integrin-mediated adhesion. Am J Physiol Cell Physiol 299:C399-410 (2010). PubMed: 20445173

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