FITC Anti-C4c+C4b 抗体 (ab4216)
Key features and details
- FITC Rabbit polyclonal to C4c+C4b
- Suitable for: IHC-P
- Reacts with: Human
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG
製品の概要
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製品名
FITC Anti-C4c+C4b antibody -
製品の詳細
FITC Rabbit polyclonal to C4c+C4b -
由来種
Rabbit -
標識
FITC. Ex: 493nm, Em: 528nm -
特異性
This antibody reacts with human C4, C4b and C4c but does not react with the C4d epitope. -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human -
免疫原
The details of the immunogen for this antibody are not available.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.3
Preservative: 0.05% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading... -
精製度
IgG fraction -
特記事項（精製）
Traces of contaminating antibodies have been removed by solid phase absorption with human plasma proteins. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab4216の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P |
Use at an assay dependent concentration.
|
| 特記事項 |
|---|
|
IHC-P
Use at an assay dependent concentration. |
ターゲット情報
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関連性
C4 plays a central role in the activation of the classical pathway of the complement system. Human complement component C4 is polymorphic at two loci, C4A and C4B. The C4A alleles carry the Rodgers (Rg) while the C4B alleles carry the Chido (Ch) blood group antigens. C4 (either allele A or B) protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase. -
細胞内局在
Secreted -
参照データベース
- Entrez Gene: 720 Human
- Entrez Gene: 721 Human
- SwissProt: P0C0L4 Human
- SwissProt: P0C0L5 Human
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別名
- Acidic complement C4 antibody
- Basic complement C4 antibody
- CH antibody
see all
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FITC Anti-C4c+C4b antibody (ab4216)
Immunohistochemistry (Formalin fixed paraffin-embedded sections) analysis of human kidney stained labelling C4C Complement with ab4216.
データシートおよび資料
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Datasheet download
参考文献 (1)
ab4216 は 1 報の論文で使用されています。
- Ispasanie E et al. Spontaneous point mutations in the capsule synthesis locus leading to structural and functional changes of the capsule in serogroup A meningococcal populations. Virulence 9:1138-1149 (2018). PubMed: 30067453
