Key features and details
- FITC Rabbit polyclonal to C4c+C4b
- Reacts with: Human
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG
製品名FITC Anti-C4c+C4b antibody
製品の詳細FITC Rabbit polyclonal to C4c+C4b
標識FITC. Ex: 493nm, Em: 528nm
特異性This antibody reacts with human C4, C4b and C4c but does not react with the C4d epitope.
C4c complement isolated from complement activated human serum.
Fluorescein isothiocyanate (FITC) isomer 1.
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保存方法Shipped at 4°C. Store at +4°C.
バッファーPreservative: 0.05% Sodium azide
Constituents: PBS, 1% BSA
Concentration information loading...
特記事項（精製）Traces of contaminating antibodies have been removed by solid phase absorption with human plasma proteins.
関連性C4 plays a central role in the activation of the classical pathway of the complement system. Human complement component C4 is polymorphic at two loci, C4A and C4B. The C4A alleles carry the Rodgers (Rg) while the C4B alleles carry the Chido (Ch) blood group antigens. C4 (either allele A or B) protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase.
- Acidic complement C4 antibody
- Basic complement C4 antibody
- CH antibody
ab4216 は 1 報の論文で使用されています。
- Ispasanie E et al. Spontaneous point mutations in the capsule synthesis locus leading to structural and functional changes of the capsule in serogroup A meningococcal populations. Virulence 9:1138-1149 (2018). PubMed: 30067453