製品名Anti-FDPS / FPS antibody
FDPS / FPS 一次抗体 製品一覧
製品の詳細Rabbit polyclonal to FDPS / FPS
アプリケーション適用あり: WB, IHC-Pmore details
Synthetic peptide corresponding to Human FDPS/ FPS aa 389-419 (internal sequence) conjugated to keyhole limpet haemocyanin.
Database link: P14324
- WB: Human cytokeratin liver cell lysate, IHC-P: Human hepatocarcinoma tissue.
Previously labelled as FDPS.
保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
バッファーPreservative: 0.09% Sodium azide
Concentration information loading...
精製度Protein G purified
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
Our Abpromise guarantee covers the use of ab38854 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000. Detects a band of approximately 44 kDa (predicted molecular weight: 41 kDa).|
|IHC-P||1/10 - 1/50.|
機能Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
パスウェイIsoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
配列類似性Belongs to the FPP/GGPP synthase family.
- Information by UniProt
- (2E antibody
- (2E,6E) farnesyl diphosphate synthase antibody
- 6E)-farnesyl diphosphate synthase antibody
Anti-FDPS / FPS antibody (ab38854) + Human cytokeratin liver cell lysate
Predicted band size: 41 kDa
Observed band size: 44 kDa why is the actual band size different from the predicted?
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human hepatocarcinoma tissue labelling FDPS / FPS with ab38854. A peroxidase-conjugated anti-rabbit IgG was used as the secondary antibody, followed by DAB staining.
This product has been referenced in:
- Abate M et al. Deregulated expression and activity of Farnesyl Diphosphate Synthase (FDPS) in Glioblastoma. Sci Rep 7:14123 (2017). Read more (PubMed: 29075041) »
- Mishra S et al. Accumulation of cholesterol and increased demand for zinc in serum-deprived RPE cells. Mol Vis 22:1387-1404 (2016). WB . Read more (PubMed: 28003730) »