Key features and details
- Sheep polyclonal to Factor IX/PTC
- Suitable for: ELISA, IHC-P, Immunoelectrophoresis
- Reacts with: Human
- Isotype: IgG
製品名Anti-Factor IX/PTC antibody
Factor IX/PTC 一次抗体 製品一覧
製品の詳細Sheep polyclonal to Factor IX/PTC
Recognizes human Factor IX/PTC as demonstrated by immunodiffusion. A single positive reactivity band was observed with Normal Human Plasma. No reaction was observed against Factor IX/PTC deficient plasma.
アプリケーション適用あり: ELISA, IHC-P, Immunoelectrophoresismore details
Full length native protein (purified) corresponding to Human Factor IX/PTC.
- Human Liver tissue
This product was previously labelled as Factor IX
保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Constituents: 0.24% HEPES, 0.58% Sodium chloride, 50% Glycerol
Concentration information loading...
精製度Ammonium Sulphate Precipitation
Our Abpromise guarantee covers the use of ab128038 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ELISA||Use at an assay dependent dilution.|
|IHC-P||Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
|Immunoelectrophoresis||Use at an assay dependent dilution.|
機能Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
組織特異性Synthesized primarily in the liver and secreted in plasma.
関連疾患Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB) [MIM:306900]; also known as Christmas disease.
Note=Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide.
Defects in F9 are the cause of thrombophilia due to factor IX defect (THR-FIX) [MIM:300807]. A hemostatic disorder characterized by a tendency to thrombosis.
配列類似性Belongs to the peptidase S1 family.
Contains 2 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 1 peptidase S1 domain.
ドメインCalcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity, to another site, beyond the Gla domain.
翻訳後修飾Activated by factor XIa, which excises the activation peptide.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
- Information by UniProt
- Christmas Disease antibody
- Christmas factor antibody
- Coagulant factor IX antibody