EI1, EZH2 inhibitor (ab269817)
Key features and details
- Potent and selective EZH2 inhibitor
- CAS Number: 1418308-27-6
Soluble in DMSO to 50 mM
- Form / State: Solid
製品の概要
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製品名
EI1, EZH2 inhibitor -
製品の詳細
Potent and selective EZH2 inhibitor -
生理活性の詳細
Potent (IC50 = 15 nM for wild-type enzyme; 13 nM for Y641F mutant enzyme) EZH2 inhibitor. Selective versus EZH1 (142-fold). Highly selective (>10,000-fold) against a panel of 10 other human methyltransferases. Inhibits cellular H3K27 methylation and activates Ezh2 target gene p16 expression in diffuse large B-cell lymphoma cells (DLBLC). Selectively inhibits growth and promotes cell cycle arrest and apoptosis of DLBLC cells with Y641 EZH2 mutations.
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CAS 番号
1418308-27-6 -
構造式
製品の特性
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体系名
6-Cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1- ethylpropyl)-1H-indole-4-carboxamide -
分子量
390.48 -
分子式
C23H26N4O2 -
PubChem 登録番号
72199293 -
保存方法
Shipped at room temperature. Store at -20°C. -
溶解性
Soluble in DMSO to 50 mM
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使用に関する注意
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CCC(CC)N1C=CC2=C(C=C(C=C21)C#N)C(=O)NCC3=C(C=C(NC3=O)C)C
画像
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Chemical Structure - EI1, EZH2 inhibitor (ab269817)
Chemical structure of EI1, EZH2 inhibitor, 1418308-27-6
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (0)
ab269817 は論文での使用が確認できていません。
