EI1, EZH2 inhibitor (ab269817)
Key features and details
- Potent and selective EZH2 inhibitor
- CAS Number: 1418308-27-6
Soluble in DMSO to 50 mM
- Form / State: Solid
製品の概要
-
製品名
EI1, EZH2 inhibitor -
製品の詳細
Potent and selective EZH2 inhibitor -
生理活性の詳細
Potent (IC50 = 15 nM for wild-type enzyme; 13 nM for Y641F mutant enzyme) EZH2 inhibitor. Selective versus EZH1 (142-fold). Highly selective (>10,000-fold) against a panel of 10 other human methyltransferases. Inhibits cellular H3K27 methylation and activates Ezh2 target gene p16 expression in diffuse large B-cell lymphoma cells (DLBLC). Selectively inhibits growth and promotes cell cycle arrest and apoptosis of DLBLC cells with Y641 EZH2 mutations.
-
CAS 番号
1418308-27-6 -
構造式
製品の特性
-
体系名
6-Cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1- ethylpropyl)-1H-indole-4-carboxamide -
分子量
390.48 -
分子式
C23H26N4O2 -
PubChem 登録番号
72199293 -
保存方法
Shipped at room temperature. Store at -20°C. -
溶解性
Soluble in DMSO to 50 mM
-
使用に関する注意
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES 線形表記
CCC(CC)N1C=CC2=C(C=C(C=C21)C#N)C(=O)NCC3=C(C=C(NC3=O)C)C
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (0)
ab269817 は論文での使用が確認できていません。