Anti-EDG2 /LPA-1 抗体 (ab23698)
Key features and details
- Rabbit polyclonal to EDG2 /LPA-1
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-EDG2 /LPA-1 antibody
EDG2 /LPA-1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to EDG2 /LPA-1 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Rat, Human
交差が予測される動物種: Xenopus laevis
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免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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ポジティブ･コントロール
- WB: Mouse liver, A549 cell lysate, Rat Liver lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, PBS -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab23698の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/200. Detects a band of approximately 43 kDa (predicted molecular weight: 41 kDa).
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| 特記事項 |
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WB
1/200. Detects a band of approximately 43 kDa (predicted molecular weight: 41 kDa). |
ターゲット情報
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機能
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation. -
組織特異性
Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes. -
配列類似性
Belongs to the G-protein coupled receptor 1 family. -
細胞内局在
Cell surface. Cell membrane. Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles. - Information by UniProt
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参照データベース
- Entrez Gene: 1902 Human
- Entrez Gene: 14745 Mouse
- Entrez Gene: 116744 Rat
- Omim: 602282 Human
- SwissProt: Q92633 Human
- SwissProt: P61793 Mouse
- SwissProt: P61794 Rat
- Unigene: 126667 Human
see all -
別名
- 5031439C20 antibody
- AI326300 antibody
- EDG 2 antibody
see all
画像
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Western blot - Anti-EDG2 /LPA-1 antibody (ab23698)All lanes : Anti-EDG2 /LPA-1 antibody (ab23698)
Lane 1 : Solubilised Mouse Liver at 50 µg
Lane 2 : A549 Cell Lysate at 40 µg
Lane 3 : Rat liver lysate at 40 µg
Predicted band size: 41 kDa
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (10)
ab23698 は 10 報の論文で使用されています。
- Wu XP et al. microRNA-329 reduces bone cancer pain through the LPAR1-dependent LPAR1/ERK signal transduction pathway in mice. Ther Adv Med Oncol 11:1758835919875319 (2019). PubMed: 31692673
- Wang H et al. Berberine Modulates LPA Function to Inhibit the Proliferation and Inflammation of FLS-RA via p38/ERK MAPK Pathway Mediated by LPA1. Evid Based Complement Alternat Med 2019:2580207 (2019). PubMed: 31781264
- Cao P et al. Autocrine lysophosphatidic acid signaling activates ß-catenin and promotes lung allograft fibrosis. J Clin Invest 127:1517-1530 (2017). PubMed: 28240604
- Kajitani N et al. Identification of Lysophosphatidic Acid Receptor 1 in Astroglial Cells as a Target for Glial Cell Line-derived Neurotrophic Factor Expression Induced by Antidepressants. J Biol Chem 291:27364-27370 (2016). PubMed: 27864362
- Zhuang Y et al. MiR-338* suppresses fibrotic pathogenesis in pulmonary fibrosis through targeting LPA1. Am J Transl Res 8:3197-205 (2016). WB ; Mouse . PubMed: 27508041
- Knowlden SA et al. Regulation of T cell motility in vitro and in vivo by LPA and LPA2. PLoS One 9:e101655 (2014). WB ; Mouse . PubMed: 25003200
- Ward Y et al. CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model. Oncogene : (2012). Mouse . PubMed: 22797060
- Schneider LV et al. Method for recovery and immunoaffinity enrichment of membrane proteins illustrated with metastatic ovarian cancer tissues. Int J Proteomics 2012:838630 (2012). PubMed: 22919487
- Zhang H et al. Proteomic analysis of bone tissues of patients with osteonecrosis of the femoral head. OMICS 13:453-66 (2009). WB ; Human . PubMed: 20001860
- Liszewska E et al. Lysophosphatidic acid signaling during embryo development in sheep: involvement in prostaglandin synthesis. Endocrinology : (2008). WB, IHC-Fr ; Sheep . PubMed: 18772233
