Anti-EBV Latent Membrane Protein 1 抗体 [CS1, CS2, CS3, CS4], prediluted (ab7502)
Key features and details
- Mouse monoclonal [CS1, CS2, CS3, CS4] to EBV Latent Membrane Protein 1, prediluted
- Suitable for: IHC-P, IHC-Fr
- Isotype: IgG1
製品の概要
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製品名
Anti-EBV Latent Membrane Protein 1 antibody [CS1, CS2, CS3, CS4], prediluted
EBV Latent Membrane Protein 1 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [CS1, CS2, CS3, CS4] to EBV Latent Membrane Protein 1, prediluted -
由来種
Mouse -
特異性
This antibody is specific to 60 kD latent membrane protein (LMP1) encoded by the BNLF1 gene of the EBV. Each clone reacts with different epitopes on the hydrophilic c-terminus of the cytoplasmic domain of LMP1. This antibody stains strongly with EBV positive lymphoblastoid cell lines and EBV infected B cell immunoblasts in infectious mononucleosis. -
アプリケーション
適用あり: IHC-P, IHC-Frmore details -
種交差性
EBV. -
免疫原
Recombinant fusion protein containing sequences of bacterial beta-galactosidase and EBV encoded Latent membrane protein.
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ポジティブ・コントロール
- Infected lymphoblastoma.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.3
Constituent: PBS -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
CS1, CS2, CS3, CS4 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab7502の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
Use at an assay dependent concentration. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
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IHC-Fr |
Use at an assay dependent concentration.
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特記事項 |
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IHC-P
Use at an assay dependent concentration. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. |
IHC-Fr
Use at an assay dependent concentration. |
ターゲット情報
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関連性
EBV is a human herpesvirus that establishes a life-long persistence in the host. The virus infects the vast majority of the world's adult population and is well known for its association with a broad spectrum of benign and malignant diseases, including infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma, and is causally associated with lymphoid and epithelial malignancies, including post-transplant lymphoproliferative disorders, Hodgkin's disease, anaplastic nasopharyngeal carcinoma and gastric carcinomas. Latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is a transforming protein that affects multiple cell signalling pathways and contributes to EBV-associated oncogenesis. LMP1 can be expressed in some states of EBV latency, and significant induction of full-length LMP1 is also observed frequently during virus reactivation into the lytic cycle. LMP1 is critical for EBV-infected cell activation, adhesion and survival, and is usually expressed in the malignant cells. -
別名
- BNLF1 antibody
- EBV antibody
- Epstein Barr virus antibody
see all
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EBV Latent Membrane Protein 1 antibody [CS1, CS2, CS3, CS4], prediluted (ab7502)
The image shows lung tissue diagnosed with Post-Transplantation Lymphoproliferative Disorder (PTLD). Mononuclear cells are stained brown with DAB chromogen around the cytoplasm - typical for Latent Membrane Protein-1 of EBV.
This picture was kindly supplied as part of the review submitted by Pradeep Rai.
データシートおよび資料
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Datasheet download
参考文献 (2)
ab7502 は 2 報の論文で使用されています。
- Li C et al. EBNA2-deleted Epstein-Barr virus (EBV) isolate, P3HR1, causes Hodgkin-like lymphomas and diffuse large B cell lymphomas with type II and Wp-restricted latency types in humanized mice. PLoS Pathog 16:e1008590 (2020). PubMed: 32542010
- Nawandar DM et al. Differentiation-Dependent LMP1 Expression Is Required for Efficient Lytic Epstein-Barr Virus Reactivation in Epithelial Cells. J Virol 91:N/A (2017). PubMed: 28179525