Anti-DR5 抗体 (ab1675)

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Key features and details

  • Goat polyclonal to DR5
  • Suitable for: IHC-P, Flow Cyt, ICC
  • Reacts with: Human
  • Isotype: IgG

製品の概要

  • 製品名

    Anti-DR5 antibody
    DR5 一次抗体 製品一覧

  • 製品の詳細

    Goat polyclonal to DR5

  • 由来種

    Goat

  • 特異性

    <0.2% cross-reactivity to TRAIL R3 peptide of the same region. Not likely to bind TRAIL R1 due to low sequence homology in this region. Antibody binds to a similar size protein from mouse spleen on Westerns.

  • アプリケーション

    適用あり: IHC-P, Flow Cyt, ICCmore details

  • 種交差性

    交差種: Human

  • 免疫原

    Synthetic peptide:

    APQQKRSSPSEGLCPPGHHISEDGRDC

    , corresponding to amino acids 68-94 of Human TRAIL Receptor 2.

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • ポジティブ･コントロール

    • Human embryonic kidney cell line-293 or human T-cell line Jurkatt.

  • 特記事項

    TRAIL R2 = "TNF Related Apoptosis Inducing Ligand Receptor 2"

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab1675 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/300.
Flow Cyt Use 1µl for 106 cells.

ab37373 - Goat polyclonal IgG, is suitable for use as an isotype control with this antibody.

 
ICC 1/300.

ターゲット情報

  • 機能

    Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

  • 組織特異性

    Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.

  • 関連疾患

    Squamous cell carcinoma of the head and neck

  • 配列類似性

    Contains 1 death domain.
    Contains 3 TNFR-Cys repeats.

  • 細胞内局在

    Membrane.
  • Information by UniProt

  • 参照データベース

    • 別名

      • Fas like protein antibody
      • Apoptosis inducing protein TRICK2A/2B antibody
      • Apoptosis inducing receptor TRAIL R2 antibody
      • CD262 antibody
      • CD262 antigen antibody
      • Cytotoxic TRAIL receptor 2 antibody
      • Death domain containing receptor for TRAIL/Apo 2L antibody
      • Death receptor 5 antibody
      • DR5 antibody
      • KILLER antibody
      • KILLER/DR5 antibody
      • OTTHUMP00000123492 antibody
      • OTTHUMP00000123493 antibody
      • p53 regulated DNA damage inducible cell death receptor(killer) antibody
      • TNF related apoptosis inducing ligand receptor 2 antibody
      • TNF-related apoptosis-inducing ligand receptor 2 antibody
      • TNFRSF10B antibody
      • TR10B_HUMAN antibody
      • TRAIL R2 antibody
      • TRAIL receptor 2 antibody
      • TRAIL-R2 antibody
      • TRAILR2 antibody
      • TRICK2 antibody
      • TRICK2A antibody
      • TRICK2B antibody
      • TRICKB antibody
      • Tumor necrosis factor receptor like protein ZTNFR9 antibody
      • Tumor necrosis factor receptor superfamily member 10B antibody
      • Tumor necrosis factor receptor superfamily, member 10b antibody
      • ZTNFR9 antibody
      see all

    画像

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DR5 antibody (ab1675)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DR5 antibody (ab1675)
      ab1675, at a dilution of 1/300, staining DR5 in human spleen section by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

    参考文献 (3)

    ab1675 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab1675 は 3 報の論文で使用されています。

    • Wagner J  et al. Dose intensification of TRAIL-inducing ONC201 inhibits metastasis and promotes intratumoral NK cell recruitment. J Clin Invest 128:2325-2338 (2018). PubMed: 29533922
    • Zhang S  et al. A novel chalcone derivative S17 induces apoptosis through ROS dependent DR5 up-regulation in gastric cancer cells. Sci Rep 7:9873 (2017). PubMed: 28852176
    • Wagner J  et al. Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212. Cell Cycle 16:1790-1799 (2017). PubMed: 28489985

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