製品の概要

  • 製品名

    DR2313 (PARP Inhibitor XI), brain-penetrant PARP inhibitor
  • 製品の詳細

    Potent, brain-penetrant and water-soluble PARP inhibitor
  • 別名

    • PARP Inhibitor XI
  • 生理活性の詳細

    Potent, brain-penetrant, and water-soluble poly(ADP-ribose) polymerase (PARP) inhibitor. IC50 values are 0.20 and 0.24 µM for PARP-1 and PARP-2, respectively. Neuroprotective in vitro and in vivo.
  • 精製度

    > 99%
  • CAS 番号

    284028-90-6
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Nakajima H  et al. A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats. J Pharmacol Exp Ther 312:472-81 (2005). Read more (PubMed: 15466246) »

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