製品の概要

  • 製品名

    Dorsomorphin (Compound C), AMP-kinase inhibitor
  • 製品の詳細

    Potent, selective and reversible AMP-kinase inhibitor. Selective for BMP signaling.
  • 別名

    • Compound C
  • 生理活性の詳細

    Potent, selective and reversible inhibitor of AMP-kinase (Ki = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable.
    Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821)
  • 精製度

    > 99%
  • CAS 番号

    866405-64-3
  • 構造式

    Chemical Structure

製品の特性

画像

  • G9a inhibition induces autophagy and autophagic cell death through AMPK/mTOR pathway.

    T24 cells (Panel G) and UMUC-3 cells (Panel H) were pre-treated with compound C (5 μM) or AICAR (1 mM) and then treated with BIX-01294 (1.5 μM) for 48 h, Cells viability was assessed by MTT assay. *P<0.01.

参考文献

This product has been referenced in:

  • Vucicevic L  et al. Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway. Autophagy 7:40-50 (2011). Read more (PubMed: 20980833) »
  • Kudo TA  et al. Dorsomorphin stimulates neurite outgrowth in PC12 cells via activation of a protein kinase A-dependent MEK-ERK1/2 signaling pathway. Genes Cells 16:1121-32 (2011). Read more (PubMed: 21988724) »
  • Zhou G  et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108:1167-74 (2001). Read more (PubMed: 11602624) »
See all 10 Publications for this product

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