Anti-Dopamine Receptor D3/DRD3 抗体 [EPR10148] (ab155098)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR10148] to Dopamine Receptor D3/DRD3
- Suitable for: WB
- Reacts with: Mouse, Human
Related conjugates and formulations
製品の概要
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製品名
Anti-Dopamine Receptor D3/DRD3 antibody [EPR10148]
Dopamine Receptor D3/DRD3 一次抗体 製品一覧 -
製品の詳細
Rabbit monoclonal [EPR10148] to Dopamine Receptor D3/DRD3 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details
適用なし: Flow Cyt,ICC/IF,IHC-P or IP -
種交差性
交差種: Mouse, Human
交差が予測される動物種: Rat -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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ポジティブ・コントロール
- SH-SY5Y, Human fetal brain and Mouse brain lysates.
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特記事項
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20ºC. -
バッファー
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
EPR10148 -
アイソタイプ
IgG -
研究分野
関連製品
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Alternative Versions
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab155098の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/1000 - 1/10000. Predicted molecular weight: 44 kDa.
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特記事項 |
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WB
1/1000 - 1/10000. Predicted molecular weight: 44 kDa. |
ターゲット情報
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機能
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. -
組織特異性
Brain. -
関連疾患
Genetic variation in DRD3 is associated with essential tremor hereditary type 1 (ETM1) [MIM:190300]. ETM1 is the most common movement disorder. The main feature is postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. -
配列類似性
Belongs to the G-protein coupled receptor 1 family. -
翻訳後修飾
Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma). -
細胞内局在
Cell membrane. Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells. - Information by UniProt
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参照データベース
- Entrez Gene: 1814 Human
- Entrez Gene: 13490 Mouse
- Entrez Gene: 29238 Rat
- Omim: 126451 Human
- SwissProt: P35462 Human
- SwissProt: P30728 Mouse
- SwissProt: P19020 Rat
- Unigene: 121478 Human
see all -
別名
- 3dopamine receptor antibody
- D antibody
- D(3) dopamine receptor antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab155098 は 3 報の論文で使用されています。
- Wysokinski A et al. Expression of Dopamine D1-4 and Serotonin 5-HT1A-3A Receptors in Blood Mononuclear Cells in Schizophrenia. Front Psychiatry 12:645081 (2021). PubMed: 33776821
- Qian X et al. Dopamine Pathway Mediated by DRD5 Facilitates Tumor Growth via Enhancing Warburg Effect in Esophageal Cancer. Front Oncol 11:655861 (2021). PubMed: 33898321
- Seo JH & Kuzhikandathil EV Dopamine D3 Receptor Mediates Preadolescent Stress-Induced Adult Psychiatric Disorders. PLoS One 10:e0143908 (2015). PubMed: 26619275