製品の概要

  • 製品名

    Donepezil hydrochloride, Acetylcholinesterase inhibitor
  • 製品の詳細

    Acetylcholinesterase inhibitor
  • 生理活性の詳細

    Potent, selective acetylcholinesterase inhibitor (IC50 = 5.7 nM). Displays >1250 times selectivity for AChE over butyrylcholinesterase. Centrally active. Neuroprotective activity in vitro and in vivo.
  • 精製度

    > 99%
  • CAS 番号

    120011-70-3
  • 構造式

    Chemical Structure

製品の特性

  • 体系名

    2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride
  • 分子量

    415.96
  • 分子式

    C24H29NO3.HCl
  • 保存方法

    Store at Room Temperature. The product can be stored for up to 12 months.
  • 溶解性

    Soluble in water to 100 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • 由来

    Synthetic

  • 研究分野

参考文献

This product has been referenced in:

  • Balducci C  et al. Reversal of visual attention dysfunction after AMPA lesions of the nucleus basalis magnocellularis (NBM) by the cholinesterase inhibitor donepezil and by a 5-HT1A receptor antagonist WAY 100635. Psychopharmacology (Berl) 167:28-36 (2003). Read more (PubMed: 12618916) »
  • Sugimoto H  et al. Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds. J Med Chem 38:4821-9 (1995). Read more (PubMed: 7490731) »
  • Ihalainen J  et al. Effects of memantine and donepezil on cortical and hippocampal acetylcholine levels and object recognition memory in rats. Neuropharmacology 61:891-9 (0). Read more (PubMed: 21704049) »

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