Dibenzazepine (ab270805)
Key features and details
- Potent gamma secretase inhbitor
- CAS Number: 209984-56-5
- Purity: >= 98%
Soluble in DMSO to 100 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Dibenzazepine -
製品の詳細
Potent gamma secretase inhbitor -
生理活性の詳細
Potent gamma secretase inhbitor (IC50 = 2.6 nM for APPL cleavage; IC50 = 2.9 nM for Notch cleavage). Inhibits Notch signaling. Neuroprotective, anti-diabetic, anti-fibrotic and cardioprotective in animal models. Blocks formation of abdominal aortic aneurysms. Inhibits AT-II induced angiogenesis and Th2 immune responses in animal aging models.
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精製度
>= 98% -
CAS 番号
209984-56-5 -
構造式
製品の特性
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体系名
N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-benzeneacetamide
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分子量
463.48 -
分子式
C26H23F2N3O3 -
PubChem 登録番号
11454028 -
保存方法
Shipped at room temperature. Store at -20°C. -
溶解性
Soluble in DMSO to 100 mM and in ethanol to 25 mM
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使用に関する注意
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)CC4=CC(=CC(=C4)F)F -
由来
Synthetic
画像
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Chemical Structure - Dibenzazepine (ab270805)
Chemical structure of Dibenzazepine, 209984-56-5
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (0)
ab270805 は論文での使用が確認できていません。
