製品の概要

  • 製品名

    Dexmedetomidine hydrochloride, alpha2 agonist
  • 製品の詳細

    Potent, highly selective α2 agonist
  • 生理活性の詳細

    Potent, highly selective α2 agonist. (Ki values are 1.08 and 1750 nM at α2 and α1 receptors, respectively). Active enantiomer of medetomidine (ab120787). Displays numerous actions including sedative, analgesic, anxiolytic, and antiulcerative properties.
  • 精製度

    > 99%
  • CAS 番号

    145108-58-3
  • 構造式

    Chemical Structure

製品の特性

  • 体系名

    4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
  • 分子量

    236.74
  • 分子式

    C13H16N2.HCl
  • 保存方法

    Store at Room Temperature. The product can be stored for up to 12 months.
  • 溶解性

    Soluble in water to 100 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • 由来

    Synthetic

  • 研究分野

参考文献

This product has been referenced in:

  • Polat B  et al. Antiulcerative effect of dexmedetomidine on indomethacin-induced gastric ulcer in rats. Pharmacol Rep 63:518-26 (2011). Read more (PubMed: 21602607) »
  • Fisher B  et al. Antinociceptive properties of intrathecal dexmedetomidine in rats. Eur J Pharmacol 192:221-5 (1991). Read more (PubMed: 1674472) »
  • Virtanen R  et al. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol 150:9-14 (1988). Read more (PubMed: 2900154) »

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