Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR7486] to Desmocollin 3 - BSA and Azide free
- Suitable for: ICC/IF, Flow Cyt, WB
- Reacts with: Mouse, Rat, Human
製品名Anti-Desmocollin 3 antibody [EPR7486] - BSA and Azide free
Desmocollin 3 一次抗体 製品一覧
製品の詳細Rabbit monoclonal [EPR7486] to Desmocollin 3 - BSA and Azide free
This antibody may cross react with Desmocollin 2. We are currently investigating.
アプリケーション適用あり: ICC/IF, Flow Cyt, WBmore details
適用なし: IHC-P or IP
種交差性交差種: Mouse, Rat, Human
Synthetic peptide within Human Desmocollin 3 aa 800-900. The exact sequence is proprietary.
Database link: Q14574
Ab248176 is the carrier-free version of ab126768. This format is designed for use in antibody labeling, including fluorochromes, metal isotopes, oligonucleotides, enzymes.
Our carrier-free formats are supplied in a buffer free of BSA, sodium azide and glycerol for higher conjugation efficiency.
Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
ab248176 is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm.
Maxpar® is a trademark of Fluidigm Canada Inc.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
保存方法Shipped at 4°C. Store at +4°C. Do Not Freeze.
解離定数（KD 値）KD = 2.40 x 10 -11 M Learn more about KD
Concentration information loading...
Our Abpromise guarantee covers the use of ab248176 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use at an assay dependent concentration.|
|Flow Cyt||Use at an assay dependent concentration.|
|WB||Use at an assay dependent concentration. Predicted molecular weight: 100 kDa.|
機能Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
組織特異性Epidermis, buccal mucosa, esophagus and cervix.
関連疾患Defects in DSC3 are the cause of hypotrichosis and recurrent skin vesicles (HRSV) [MIM:613102]. A disorder characterized by hypotrichosis and the appearance of recurrent skin vesicle formation. Affected individuals show sparse and fragile hair on scalp, as well as absent eyebrows and eyelashes. Vesicles filled with thin, watery fluid are observed on the scalp and skin of most of the boby. Mucosal vesicles are absent.
配列類似性Contains 5 cadherin domains.
ドメインCalcium may be bound by the cadherin-like repeats.
細胞内局在Cell membrane. Cell junction > desmosome.
- Information by UniProt
- Cadherin family member 3 antibody
- CDHF3 antibody
- desmocollin 3a/3b antibody
All lanes : Anti-Desmocollin 3 antibody [EPR7486] (ab126768) at 1/10000 dilution
Lane 1 : A431 cell lysate
Lane 2 : Human skin lysate
Lane 3 : Human espophagus lysate
Lysates/proteins at 10 µg per lane.
All lanes : Goat anti-Rabbit HRP at 1/2000 dilution
Predicted band size: 100 kDa
This data was developed using ab126768, the same antibody clone in a different buffer formulation.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.