Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR7486] to Desmocollin 3
- Suitable for: WB, Flow Cyt, ICC/IF
- Reacts with: Mouse, Rat, Human
製品名Anti-Desmocollin 3 antibody [EPR7486]
Desmocollin 3 一次抗体 製品一覧
製品の詳細Rabbit monoclonal [EPR7486] to Desmocollin 3
特異性This antibody may cross react with Desmocollin 2. We are currently investigating.
アプリケーション適用あり: WB, Flow Cyt, ICC/IFmore details
適用なし: IHC-P or IP
種交差性交差種: Mouse, Rat, Human
Synthetic peptide, corresponding to residues in Human Desmocollin 3 (Q14574).
- A431, Human skin, and Human espophagus lysates; and A431 cells.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
解離定数（KD 値）KD = 2.40 x 10 -11 M Learn more about KD
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue culture supernatant
Concentration information loading...
精製度Tissue culture supernatant
Our Abpromise guarantee covers the use of ab126768 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/10000 - 1/50000. Predicted molecular weight: 100 kDa.|
|Flow Cyt||1/10 - 1/100.
ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
|ICC/IF||1/100 - 1/250.|
機能Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
組織特異性Epidermis, buccal mucosa, esophagus and cervix.
関連疾患Defects in DSC3 are the cause of hypotrichosis and recurrent skin vesicles (HRSV) [MIM:613102]. A disorder characterized by hypotrichosis and the appearance of recurrent skin vesicle formation. Affected individuals show sparse and fragile hair on scalp, as well as absent eyebrows and eyelashes. Vesicles filled with thin, watery fluid are observed on the scalp and skin of most of the boby. Mucosal vesicles are absent.
配列類似性Contains 5 cadherin domains.
ドメインCalcium may be bound by the cadherin-like repeats.
細胞内局在Cell membrane. Cell junction > desmosome.
- Information by UniProt
- Cadherin family member 3 antibody
- CDHF3 antibody
- desmocollin 3a/3b antibody
All lanes : Anti-Desmocollin 3 antibody [EPR7486] (ab126768) at 1/10000 dilution
Lane 1 : A431 lysates
Lane 2 : Human skin lysates
Lane 3 : Human espophagus lysates
Lysates/proteins at 10 µg per lane.
All lanes : Goat anti-Rabbit HRP at 1/2000 dilution
Predicted band size: 100 kDa
ab126768 at 1/10 dilution staining Desmocollin 3 in permeabilized A431 cells by Flow cytometry (red) compared with a rabbit IgG negative control (green).
Equilibrium disassociation constant (KD)
Learn more about KD
Click here to learn more about KD
ab126768 は 1 報の論文で使用されています。
- Passantino L et al. Sodium metavanadate exhibits carcinogenic tendencies in vitro in immortalized human bronchial epithelial cells. Metallomics 5:1357-67 (2013). WB ; Human . PubMed: 23963610