製品名Anti-DEF6 antibody [EPR7492] - BSA and Azide free
DEF6 一次抗体 製品一覧
製品の詳細Rabbit monoclonal [EPR7492] to DEF6 - BSA and Azide free
アプリケーション適用あり: ICC, Flow Cyt, IP, WBmore details
Synthetic peptide within Human DEF6 aa 600-700 (C terminal). The exact sequence is proprietary.
Database link: Q9H4E7
ab248188 is the carrier-free version of ab126792 This format is designed for use in antibody labeling, including fluorochromes, metal isotopes, oligonucleotides, enzymes.
Our carrier-free formats are supplied in a buffer free of BSA, sodium azide and glycerol for higher conjugation efficiency.
Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Ab248188 is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm.
Maxpar® is a trademark of Fluidigm Canada Inc.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
解離定数（KD 値）KD = 2.01 x 10 -10 M Learn more about KD
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Our Abpromise guarantee covers the use of ab248188 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC||Use at an assay dependent concentration.|
|Flow Cyt||Use at an assay dependent concentration.|
|IP||Use at an assay dependent concentration.|
|WB||Use at an assay dependent concentration. Detects a band of approximately 74 kDa (predicted molecular weight: 74 kDa).|
機能Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP-70 signaling.
組織特異性Broadly expressed in the immune system and can be detected in T and B-cells.
配列類似性Contains 1 PH domain.
ドメインThe PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding.
翻訳後修飾Tyrosine-phosphorylated by tyrosine-protein kinase LCK in response to T-cell activation.
細胞内局在Cytoplasm. Cell membrane. Nucleus. Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate.
- Information by UniProt
- DEF-6 antibody
- Def6 antibody
- DEFI6_HUMAN antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.