DAPTA, CCR5 antagonist (ab120810)
Key features and details
- Potent, selective CCR5 antagonist
- CAS Number: 106362-34-9
- Purity: > 95%
- Soluble in water to 1 mg/ml
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
DAPTA, CCR5 antagonist -
製品の詳細
Potent, selective CCR5 antagonist -
生理活性の詳細
Potent, selective CCR5 antagonist. Synthetic peptide. Selective antiviral entry inhibitor for R5 tropic HIV-1 isolates. Able to attenuate neuroinflammation.
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精製度
> 95% -
CAS 番号
106362-34-9 -
構造式
製品の特性
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分子量
856.89 -
分子式
C35H56N10O15 -
配列
ASTTTNYT (Modifications: C-terminal amide; Ala-1 = D-Ala) -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 1 mg/ml -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (2)
ab120810 は 2 報の論文で使用されています。
- Yu W et al. miR-4456/CCL3/CCR5 Pathway in the Pathogenesis of Tight Junction Impairment in Chronic Obstructive Pulmonary Disease. Front Pharmacol 12:551839 (2021). PubMed: 33953665
- Gao R et al. R5 HIV-1 gp120 Activates p38 MAPK to Induce Rat Cardiomyocyte Injury by the CCR5 Coreceptor. Pathobiology 86:274-284 (2019). PubMed: 31574524