Daminozide, histone demethylase KDM2/7 subfamily inhibitor (ab144621)

Selective histone demethylase KDM2/7 subfamily inhibitor (IC₅₀ values are 0.55, 1.5 and 2.1 μM for PHF8, KDM2A and KDM7A respectively). Exhibits ≥ 60-fold selectivity for KDM2/7 demethylases over other histone demethylases (KDM3, KDM4, KDM5, KDM6) and 2-oxoglurate oxygenases (FIH, PHD2, BBOX1) (IC₅₀ values >100 μM). Active in vitro. Cell-permeable.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Synthetic

• Epigenetics and Nuclear Signaling
• Chromatin Modifying Enzymes
• Methylation

• Epigenetics and Nuclear Signaling
• Transcription
• Domain Families
• Zinc Finger

• Signal Transduction
• Signaling Pathway
• Nuclear Signaling
• Nuclear Hormone Receptors
• Estrogen

• Epigenetics and Nuclear Signaling
• Nuclear Signaling Pathways
• Nuclear Receptors
• Estrogen

• Epigenetics and Nuclear Signaling
• Transcription
• Co-factors

• Epigenetics and Nuclear Signaling
• Chromatin Modifying Enzymes
• Jumonji containing proteins

• Epigenetics and Nuclear Signaling
• Chromatin Modifying Enzymes
• Methylation
• Lysine demethylation

• Cancer
• Signal transduction
• Nuclear signaling
• Nuclear hormone receptors
• Estrogen

• Metabolism
• Pathways and Processes
• Mitochondrial Metabolism
• Mitochondrial Biogenesis

• Metabolism
• Pathways and Processes
• Metabolic signaling pathways
• Nucleotide metabolism
• Molecular processes
• Mitochondrial transcription