DAMGO, mu opioid receptor agonist (ab120674)
Key features and details
- Potent and selective μ opioid receptor agonist
- CAS Number: 78123-71-4
- Purity: > 95%
- Soluble in water to 1 mg/ml
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
DAMGO, mu opioid receptor agonist -
製品の詳細
Potent and selective μ opioid receptor agonist -
生理活性の詳細
Potent and selective μ opioid receptor agonist (Ki values are 2.0, >1000 and >1000 nM for opioid receptor subtypes μ, κ and δ, respectively). Partial central activity following systemic administration. Antinociceptive.
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精製度
> 95% -
CAS 番号
78123-71-4 -
構造式
製品の特性
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分子量
513.59 -
分子式
C26H35N5O6 -
配列
YAGFG (Modifications: C-terminal alcohol; Ala-2 = D-Ala; Phe-4 = N-Me) -
PubChem 登録番号
5462471 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 1 mg/ml -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
C[C@H](C(=O)NCC(=O)N(C)[C@@H](CC1=CC=CC=C1)C(=O)NCCO)NC(=O)[C@H](CC2=CC=C(C=C2)O)N -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (2)
ab120674 は 2 報の論文で使用されています。
- Bachmutsky I et al. Opioids depress breathing through two small brainstem sites. Elife 9:N/A (2020). PubMed: 32073401
- Bull FA et al. Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by ß-arrestin2 and c-Src. Sci Rep 7:9969 (2017). PubMed: 28855588
