DAMGO, mu opioid receptor agonist (ab120674)
- データシート
- 文献 (1)
製品の概要
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製品名
DAMGO, mu opioid receptor agonist -
製品の詳細
Potent and selective μ opioid receptor agonist -
生理活性の詳細
Potent and selective μ opioid receptor agonist (Ki values are 2.0, >1000 and >1000 nM for opioid receptor subtypes μ, κ and δ, respectively). Partial central activity following systemic administration. Antinociceptive. -
精製度
> 95% -
CAS 番号
78123-71-4 -
構造式
製品の特性
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分子量
513.59 -
分子式
C26H35N5O6 -
配列
YAGFG (Modifications: C-terminal alcohol; Ala-2 = D-Ala; Phe-4 = N-Me) -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 1 mg/ml -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
Synthetic
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研究分野
参考文献
This product has been referenced in:
- Lowery JJ et al. Glycosylation improves the central effects of DAMGO. Chem Biol Drug Des 69:41-7 (2007). Read more (PubMed: 17313456) »
- Shin MS & Helmstetter FJ Antinociception following application of DAMGO to the basolateral amygdala results from a direct interaction of DAMGO with Mu opioid receptors in the amygdala. Brain Res 1064:56-65 (2005). Read more (PubMed: 16289487) »
- Raynor K et al. Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol 45:330-4 (1994). Read more (PubMed: 8114680) »
