Anti-Cytokeratin 1 抗体 [AE1] (ab9286)
Key features and details
- Mouse monoclonal [AE1] to Cytokeratin 1
- Reacts with: Mouse, Rat, Rabbit, Chicken, Cow, Monkey, Turtle
- Isotype: IgG1
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Cytokeratin 1 antibody [AE1]
Cytokeratin 1 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [AE1] to Cytokeratin 1 -
由来種
Mouse -
特異性
This antibody recognises most of the acidic (Type 1) keratins. -
種交差性
交差種: Mouse, Rat, Rabbit, Chicken, Cow, Monkey, Turtle -
免疫原
Full length native protein (purified) corresponding to Human Cytokeratin 1. Epidermal keratin
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.3
Preservative: 0.1% Sodium azide -
Concentration information loading...
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精製度
Tissue culture supernatant -
ポリ/モノ
モノクローナル -
クローン名
AE1 -
ミエローマ
unknown -
アイソタイプ
IgG1 -
軽鎖の種類
unknown -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
ターゲット情報
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機能
May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). -
組織特異性
The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis. -
関連疾患
Defects in KRT1 are a cause of bullous congenital ichthyosiform erythroderma (BCIE) [MIM:113800]; also known as epidermolytic hyperkeratosis (EHK) or bullous erythroderma ichthyosiformis congenita of Brocq. BCIE is an autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.
Defects in KRT1 are the cause of ichthyosis hystrix Curth-Macklin type (IHCM) [MIM:146590]. IHCM is a genodermatosis with severe verrucous hyperkeratosis. Affected individuals manifest congenital verrucous black scale on the scalp, neck, and limbs with truncal erythema, palmoplantar keratoderma and keratoses on the lips, ears, nipples and buttocks.
Defects in KRT1 are a cause of palmoplantar keratoderma non-epidermolytic (NEPPK) [MIM:600962]. NEPKK is a dermatological disorder characterized by focal palmoplantar keratoderma with oral, genital, and follicular lesions.
Defects in KRT1 are a cause of ichthyosis annular epidermolytic (AEI) [MIM:607602]; also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI is a skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.
Defects in KRT1 are the cause of palmoplantar keratoderma striate type 3 (SPPK3) [MIM:607654]; also known as keratosis palmoplantaris striata III. SPPK3 is a dermatological disorder affecting palm and sole skin where stratum corneum and epidermal layers are thickened. There is no involvement of non-palmoplantar skin, and both hair and nails are normal. -
配列類似性
Belongs to the intermediate filament family. -
翻訳後修飾
Undergoes deimination of some arginine residues (citrullination). -
細胞内局在
Cell membrane. Located on plasma membrane of neuroblastoma NMB7 cells. - Information by UniProt
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参照データベース
- Entrez Gene: 100301161 Cow
- Entrez Gene: 281266 Cow
- Entrez Gene: 16678 Mouse
- Entrez Gene: 300250 Rat
- SwissProt: P04104 Mouse
- SwissProt: Q6IMF3 Rat
- Unigene: 183137 Mouse
- Unigene: 31789 Rat
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別名
- 67 kDa cytokeratin antibody
- CK-1 antibody
- CK1 antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (12)
ab9286 は 12 報の論文で使用されています。
- Choo MK et al. The protein kinase p38a destabilizes p63 to limit epidermal stem cell frequency and tumorigenic potential. Sci Signal 11:N/A (2018). PubMed: 30301786
- Yin C et al. TLR7-expressing cells comprise an interfollicular epidermal stem cell population in murine epidermis. Sci Rep 4:5831 (2014). PubMed: 25060222
- Caballero-Franco C et al. Tuning of protein kinase circuitry by p38a is vital for epithelial tissue homeostasis. J Biol Chem 288:23788-97 (2013). PubMed: 23836897
- Spagnolo DV et al. Monoclonal anti-keratin (AE1) reactivity in routinely processed tissue from 166 human neoplasms. Am J Clin Pathol 84:697-704 (1985). PubMed: 2416215
- Sun TT et al. Monoclonal antibody studies of mammalian epithelial keratins: a review. Ann N Y Acad Sci 455:307-29 (1985). PubMed: 2417518