Anti-CYFIP2 抗体 (ab95969)
Key features and details
- Rabbit polyclonal to CYFIP2
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-CYFIP2 antibody -
製品の詳細
Rabbit polyclonal to CYFIP2 -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat -
免疫原
Recombinant fragment, corresponding to a region within amino acids 346-610 of Human CYFIP2 (UniProt ID: Q96F07 isoform 2; NP_055191).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab95969の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB | (1) |
1/500 - 1/3000. Predicted molecular weight: 146 kDa.
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IHC-P |
1/100 - 1/500.
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特記事項 |
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WB
1/500 - 1/3000. Predicted molecular weight: 146 kDa. |
IHC-P
1/100 - 1/500. |
ターゲット情報
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関連性
CYFIP2 is involved in T cell adhesion and p53 dependent induction of apoptosis. It does not bind RNA but is up regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis. There are 2 isoforms produced by alternative splicing. -
細胞内局在
Cytoplasm perinuclear region. Cell junction, synapse, synaptosome. Treatment with leptomycin-B triggers translocation to the nucleus. -
参照データベース
- Entrez Gene: 26999 Human
- Entrez Gene: 76884 Mouse
- Entrez Gene: 303073 Rat
- Omim: 606323 Human
- SwissProt: Q96F07 Human
- SwissProt: Q5SQX6 Mouse
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別名
- CYFP2 antibody
- cytoplasmic FMR1 interacting protein 2 antibody
- KIAA1168 antibody
see all
画像
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (9)
ab95969 は 9 報の論文で使用されています。
- Petrick HL et al. Adipose Tissue Inflammation Is Directly Linked to Obesity-Induced Insulin Resistance, while Gut Dysbiosis and Mitochondrial Dysfunction Are Not Required. Function (Oxf) 1:zqaa013 (2020). WB . PubMed: 34278304
- Zhang Y et al. Enhanced Prefrontal Neuronal Activity and Social Dominance Behavior in Postnatal Forebrain Excitatory Neuron-Specific Cyfip2 Knock-Out Mice. Front Mol Neurosci 13:574947 (2020). PubMed: 33192297
- Lee SH et al. Haploinsufficiency of Cyfip2 Causes Lithium-Responsive Prefrontal Dysfunction. Ann Neurol 88:526-543 (2020). PubMed: 32562430
- Zhang Y et al. Differential cell-type-expression of CYFIP1 and CYFIP2 in the adult mouse hippocampus. Anim Cells Syst (Seoul) 23:380-383 (2019). PubMed: 31853374
- Marsden KC et al. A Cyfip2-Dependent Excitatory Interneuron Pathway Establishes the Innate Startle Threshold. Cell Rep 23:878-887 (2018). IHC ; Zebrafish . PubMed: 29669291
- Han K et al. Fragile X-like behaviors and abnormal cortical dendritic spines in cytoplasmic FMR1-interacting protein 2-mutant mice. Hum Mol Genet 24:1813-23 (2015). PubMed: 25432536
- Taha MS et al. Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin. PLoS One 9:e91465 (2014). ICC/IF ; Human . PubMed: 24658146
- Han K et al. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature 503:72-7 (2013). Mouse . PubMed: 24153177
- Mongroo PS et al. IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2. Cancer Res 71:2172-82 (2011). WB ; Human . PubMed: 21252116