Anti-CXCR3 抗体 - C-terminal (ab181013)
Key features and details
- Rabbit polyclonal to CXCR3 - C-terminal
- Suitable for: ICC/IF, WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-CXCR3 antibody - C-terminal
CXCR3 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to CXCR3 - C-terminal -
由来種
Rabbit -
特異性
At least two isoforms of CXCR3 are known to exist and ab181013 will detect both isoforms. -
アプリケーション
適用あり: ICC/IF, WBmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide corresponding to Human CXCR3 (C terminal). 19 amino acid peptide.
Database link: P49682-2 -
ポジティブ・コントロール
- WB: HepG2 cell lysate. ICC: HepG2 cells
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab181013の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ICC/IF |
Use a concentration of 5 - 20 µg/ml.
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WB |
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 43 kDa (predicted molecular weight: 46 kDa).
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特記事項 |
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ICC/IF
Use a concentration of 5 - 20 µg/ml. |
WB
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 43 kDa (predicted molecular weight: 46 kDa). |
ターゲット情報
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機能
Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC).
Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). May play a role in angiogenesis.
Isoform 3 mediates the activity of CXCL11. -
組織特異性
Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. -
配列類似性
Belongs to the G-protein coupled receptor 1 family. -
細胞内局在
Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 2833 Human
- Omim: 300574 Human
- SwissProt: P49682 Human
- Unigene: 198252 Human
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別名
- C-X-C chemokine receptor type 3 antibody
- CD 183 antibody
- CD182 antibody
see all
画像
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Lane 1 : Anti-CXCR3 antibody - C-terminal (ab181013) at 1 µg/ml
Lane 2 : Anti-CXCR3 antibody - C-terminal (ab181013) at 2 µg/ml
All lanes : HepG2 cell lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 46 kDa -
Immunocytochemistry analysis of HepG2 cells labeling CXCR3 using ab181013 at 5 µg/ml.
データシートおよび資料
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Datasheet download
参考文献 (2)
ab181013 は 2 報の論文で使用されています。
- Lv ZT et al. FNDC4 Inhibits RANKL-Induced Osteoclast Formation by Suppressing NF-?B Activation and CXCL10 Expression. Biomed Res Int 2018:3936257 (2018). PubMed: 29977911
- Yu J et al. Advanced glycation end products induce the apoptosis of and inflammation in mouse podocytes through CXCL9-mediated JAK2/STAT3 pathway activation. Int J Mol Med 40:1185-1193 (2017). PubMed: 28849106