製品の概要

  • 製品名

    Curcumin (Diferuloylmethane), Lipooxygenase inhibitor
  • 製品の詳細

    Flavonoid. Lipooxygenase inhibitor. Antioxidant, anti-inflammatory agent.
  • 別名

    • Diferuloylmethane
  • 生理活性の詳細

    Flavonoid derived from Curcuma longa plant. Potent antioxidant, anti-inflammatory, analgesic and anticancer agent. Lipooxygenase and cyclooxygenase inhibitor (IC50 values are 8 and 52 μM, respectively). Blood-brain barrier permeable. Shows diverse range of actions including free radical scavenging activity in vitro and in vivo, cardio and neuroprotective effects.
  • CAS 番号

    458-37-7
  • 構造式

    Chemical Structure

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab120618 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Functional Studies Use at an assay dependent concentration.

画像

  • ab32137 staining c-Jun in HeLa cells treated with curcumin (diferuloylmethane) (ab120618), by ICC/IF. Decrease in c-Jun expression correlates with increased concentration of curcumin (diferuloylmethane) as described in literature.
    The cells were incubated at 37°C for 4h in media containing different concentrations of ab120618 (curcumin (diferuloylmethane)) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab32137 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

参考文献

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