Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR6463] to CSN7A - BSA and Azide free
- Suitable for: WB
- Reacts with: Rat, Human
製品名Anti-CSN7A antibody [EPR6463] - BSA and Azide free
CSN7A 一次抗体 製品一覧
製品の詳細Rabbit monoclonal [EPR6463] to CSN7A - BSA and Azide free
アプリケーション適用あり: WBmore details
適用なし: Flow Cyt,ICC/IF,IHC-P or IP
種交差性交差種: Rat, Human
Synthetic peptide within Human CSN7A aa 200-300. The exact sequence is proprietary.
Database link: Q9UBW8
ab247971 is the carrier-free version of ab124705 This format is designed for use in antibody labeling, including fluorochromes, metal isotopes, oligonucleotides, enzymes.
Our carrier-free formats are supplied in a buffer free of BSA, sodium azide and glycerol for higher conjugation efficiency.
Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Ab247971 is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm.
Maxpar® is a trademark of Fluidigm Canada Inc.
Mouse: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information. This product was previously labelled as COPS7A
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
解離定数（KD 値）KD = 1.35 x 10 -10 M Learn more about KD
Concentration information loading...
Our Abpromise guarantee covers the use of ab247971 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use at an assay dependent concentration. Predicted molecular weight: 30 kDa.|
機能Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
組織特異性Widely expressed. Expressed at high level in brain, heart and skeletal muscle.
配列類似性Belongs to the CSN7/EIF3M family. CSN7 subfamily.
Contains 1 PCI domain.
翻訳後修飾Phosphorylated by CK2 and PKD kinases.
- Information by UniProt
- COP9 complex subunit 7a antibody
- COP9 constitutive photomorphogenic homolog subunit 7A antibody
- COP9 signalosome complex subunit 7a antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.