Corticosterone, endogenous steroid hormone (ab143597)
Key features and details
- Potent endogenous glucocorticoid and mineralocorticoid receptor agonist
- CAS Number: 50-22-6
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Corticosterone, endogenous steroid hormone -
製品の詳細
Potent endogenous glucocorticoid and mineralocorticoid receptor agonist -
精製度
> 98% -
CAS 番号
50-22-6 -
構造式
製品の特性
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体系名
(8S,9S,10R,11S,13S,14S,17S)-11-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one -
分子量
346.46 -
分子式
C21H30O4 -
PubChem 登録番号
5753 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM and in ethanol to 10 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (7)
ab143597 は 7 報の論文で使用されています。
- Guo S et al. Chronic Corticosterone Exposure Suppresses Copper Transport through GR-Mediated Intestinal CTR1 Pathway in Mice. Biology (Basel) 12:N/A (2023). PubMed: 36829476
- Wu G & Wu Y Neuroprotective effect of Kurarinone against corticosterone-induced cytotoxicity on rat hippocampal neurons by targeting BACE1 to activate P13K-AKT signaling - A potential treatment in insomnia disorder. Pharmacol Res Perspect 11:e01132 (2023). PubMed: 37740616
- Gao C et al. Naringin Mediates Adult Hippocampal Neurogenesis for Antidepression via Activating CREB Signaling. Front Cell Dev Biol 10:731831 (2022). PubMed: 35478969
- Zhang B et al. The Dual Dose-Dependent Effects of Corticosterone on Hippocampal Cell Apoptosis After Traumatic Brain Injury Depend on the Activation Ratio of Mineralocorticoid Receptors to Glucocorticoid Receptors. Front Pharmacol 12:713715 (2021). PubMed: 34381366
- Zhang B et al. Corticosteroid receptor rebalancing alleviates critical illness-related corticosteroid insufficiency after traumatic brain injury by promoting paraventricular nuclear cell survival via Akt/CREB/BDNF signaling. J Neuroinflammation 17:318 (2020). PubMed: 33100225
- Li M et al. Protein Kinase C Mediates the Corticosterone-induced Sensitization of Dorsal Root Ganglion Neurons Innervating the Rat Stomach. J Neurogastroenterol Motil 23:464-476 (2017). Rat . PubMed: 28343377
- Perry RJ et al. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell 160:745-758 (2015). PubMed: 25662011