Anti-Cortical Thymocytes 抗体 [ICO-44] (ab24235)

CTXL, a cortical thymocyte marker is a member of the immunoglobulin (Ig) superfamily and has features of both antigen specific receptors and adhesion molecules. This protein contains a signal peptide, an extracellular V type Ig like domain followed by a C2 type Ig like domain, a transmembrane region devoid of charged residues, and a cytoplasmic tail. There are multiple N glycosylation sites in the extracellular region and phosphorylation sites in the cytoplasmic tail. Northern blot analysis revealed CTH expression in stomach, colon, prostate, trachea, and thyroid gland, with lower levels in bladder and lung. CTH expression was not detected in thymus, although CTH could be amplified by PCR from a thymus cDNA library.

Type I membrane protein.