VEGF ~ 注目ターゲット

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ウサギ・モノクローナル 抗体

ターゲット名

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適用

文献

製品番号

VEGFAHu, MsFlow Cyt, ICC/IF, IHC-P, IP, WB18ab52917
VEGFAHuIHC-P4ab27620
VEGFA Hu, MsFlow Cyt, ICC/IF, IHC-P, IP4ab185238
VEGFA
Alexa Fluor® 594
HuICC/IFab206888
VEGFA
Alexa Fluor® 647
HuICC/IFab206887
VEGF Receptor 1 Ms, Rat, Hu, ChHmIHC-Fr, IHC-P, IP, WB84ab32152
VEGF Receptor 2 HuIP, WB3ab134191
VEGF Receptor 2HuIHC-Pab115805

抗体

ターゲット名

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文献数

製品番号

VEGFA
Alexa Fluor® 488
Ms-M HuICC/IFab201996
VEGFAMs-M Ms, Rat, Dog, Hu, RbELISA, ICC, ICC/IF, IHC-Fr, IHC-P, IP, WB79ab1316
VEGFARb-PHu, Ms, RatELISA, WB180ab46154
VEGFARb-P
HuICC/IF, IHC-FoFr, IHC-FrFl, IHC-P, IP8ab39250
VEGF Receptor 1Rb-P
Hu, Ms, Rat, PigEM, ICC/IF, IHC-Fr, IHC-P, WB32ab2350
VEGF Receptor 2Rb-PHu, Ms, Rat, Cow, DogFlow Cyt, ICC/IF, IHC-Fr, IHC-P, IP54ab2349
VEGF Receptor 2Rb-PHu, Ms, RatIHC-FoFr, IHC-P, WB22ab39256
VEGF Receptor 3Rb-P
Ms, Rat, HuICC/IF, IHC - Wmt, IHC-P, WB15ab27278
VEGF Receptor 3Rb-P
HuIHC-P1ab15295
VEGFA 抗体一覧VEGF Receptor 抗体一覧

抗体アレイ

製品名

製品番号

Acute Kidney Injury Human Membrane Antibody Array (20 targets)

Target : KIM-1, Albumin (ALB), Osteopontin (Osteopontin), Trefoil Factor 3 (TFF3), B2M, Clusterin (CLU), CXCL16, Osteoactivin, Liver-type fatty acid binding protein (L-FABP), MCP-1, sTNFRI, Calbindin (CALB1), Interferon gamma-induced protein 10 (IP-10), Cystatin C, HGF, MIF, NGAL, TIMP-1, VCAM-1, VEGF-A

ab169806
Angiogenesis Human Membrane Antibody Array (20 Targets)

Target : Angiogenin, EGF, ENA-78, bFGF, GRO, IFN-gamma, IGF-I, IL-6, IL-8, Leptin, MCP-1, PDGF-BB, PIGF, RANTES, TGF-beta1, TIMP-1, TIMP-2, Thrombopoietin, VEGF-A, VEGF-D

ab134000
Angiogenesis Human Membrane Antibody Array (23 targets)

Target : Angiopoietin 1, Angiopoietin 2, Angiostatin, Endostatin, G-CSF, GM-CSF, I-309, IL-10, IL-1 alpha, IL-1 beta, IL-2, IL-4, I-TAC, MCP-3, MCP-4, MMP-1, MMP-9, PECAM-1, Tie-2, TNF alpha, uPAR, VEGFR2, VEGFR3

ab169808
抗体アレイ一覧

キット

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容量

製品番号

VEGF ELISA KitMs1x96testsab209882
VEGF ELISA KitHu1x96testsab100662
VEGF ELISA KitRat1x96testsab100786
VEGF ELISA KitMs1x96testsab100751
VEGF Receptor 1 ELISA Kit (FLT1) Hu1x96testsab195210
VEGF Receptor 2 ELISA Kit Hu1x96testsab213476
VEGF Receptor 3 ELISA Kit (FLT4) Ms1x96testsab203367
キット一覧

インヒビター

製品名

解説

製品番号

AAL-993Potent, selective and cell-permeable VEGFR inhibitorab141590
SU 6668Potent PDGFR inhibitor (IC50 = 60 nM). Also inhibits VEGFR2 and FGFR1 (IC50 values are 2 and 3 μM respectively). ab142156
SU 1498Selective VEGFR2 inhibitorab141447
SU4312Potent, selective VEGFR and PDGFR receptor tyrosine kinase inhibitorab141577
VEGFR2 Kinase Inhibitor IA highly selective, cell-permeable receptor tyrosine kinase (RTK) inhibitor (IC50 = 70 nM) for murine vascular endothelial growth factor receptor 2 (VEGF-R2; KDR/Flk-1).ab145888
Royal jelly acid (10-Hydroxy-2-decenoic acid)VEGF inhibitorab144050
SU-5402Potent, selective VEGFR and FGFR inhibitorab141368

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

VEGF 165A proteinHuCellAct, CellDiff, FuncS, SDS-PAGEab9571
VEGF proteinHuSDS-PAGE, WBab55566
VEGF Receptor 1 proteinHuFuncS, SDS-PAGE, WBab84771
VEGFC proteinHuSDS-PAGEab83573
VEGF Receptor 2 protein HuFuncS, SDS-PAGEab106310
タンパク質・ペプチド一覧

VEGF について

5 種類のサブタイプと PIGF で VEGF ファミリーを形成している。また受容体は主に内皮細胞に存在し、VEGFR-1~3 の 3 種のチロシンキナーゼ型受容体と分泌型 VEGFR-1 および NRP-1 (ニューロピリン) が報告されている。
実験医学増刊 Vol.28 No.17 特集 「血管研究と血管治療」 (羊土社) より

Function
機能
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
Tissue specificity
組織特異性
Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed.
Involvement in disease
疾患関連性
Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1) [MIM:603933]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
Sequence similarities
配列類似性
Belongs to the PDGF/VEGF growth factor family.
Cellular localization
細胞内局在性
Secreted. VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.

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