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ターゲット名 | 交差種 | 適用 | ||||||
---|---|---|---|---|---|---|---|---|
VEGFA | Hu, Ms | Flow Cyt, ICC/IF, IHC-P, IP, WB | 18 | ab52917 | ||||
VEGFA | Hu | IHC-P | 4 | ab27620 | ||||
VEGFA | Hu, Ms | Flow Cyt, ICC/IF, IHC-P, IP | 4 | ab185238 | ||||
VEGFA | Hu | ICC/IF | ab206888 | |||||
VEGFA | Hu | ICC/IF | ab206887 | |||||
VEGF Receptor 1 | Ms, Rat, Hu, ChHm | IHC-Fr, IHC-P, IP, WB | 84 | ab32152 | ||||
VEGF Receptor 2 | Hu | IP, WB | 3 | ab134191 | ||||
VEGF Receptor 2 | Hu | IHC-P | ab115805 |
ターゲット名 | 交差種 | 適用 | 文献数 | ||||||
---|---|---|---|---|---|---|---|---|---|
VEGFA | Ms-M | Hu | ICC/IF | ab201996 | |||||
VEGFA | Ms-M | Ms, Rat, Dog, Hu, Rb | ELISA, ICC, ICC/IF, IHC-Fr, IHC-P, IP, WB | 79 | ab1316 | ||||
VEGFA | Rb-P | Hu, Ms, Rat | ELISA, WB | 180 | ab46154 | ||||
VEGFA | Rb-P | Hu | ICC/IF, IHC-FoFr, IHC-FrFl, IHC-P, IP | 8 | ab39250 | ||||
VEGF Receptor 1 | Rb-P | Hu, Ms, Rat, Pig | EM, ICC/IF, IHC-Fr, IHC-P, WB | 32 | ab2350 | ||||
VEGF Receptor 2 | Rb-P | Hu, Ms, Rat, Cow, Dog | Flow Cyt, ICC/IF, IHC-Fr, IHC-P, IP | 54 | ab2349 | ||||
VEGF Receptor 2 | Rb-P | Hu, Ms, Rat | IHC-FoFr, IHC-P, WB | 22 | ab39256 | ||||
VEGF Receptor 3 | Rb-P | Ms, Rat, Hu | ICC/IF, IHC - Wmt, IHC-P, WB | 15 | ab27278 | ||||
VEGF Receptor 3 | Rb-P | Hu | IHC-P | 1 | ab15295 | ||||
VEGFA 抗体一覧 | VEGF Receptor 抗体一覧 |
製品名 | 製品番号 | |||||
---|---|---|---|---|---|---|
Acute Kidney Injury Human Membrane Antibody Array (20 targets) Target : KIM-1, Albumin (ALB), Osteopontin (Osteopontin), Trefoil Factor 3 (TFF3), B2M, Clusterin (CLU), CXCL16, Osteoactivin, Liver-type fatty acid binding protein (L-FABP), MCP-1, sTNFRI, Calbindin (CALB1), Interferon gamma-induced protein 10 (IP-10), Cystatin C, HGF, MIF, NGAL, TIMP-1, VCAM-1, VEGF-A |
ab169806 | |||||
Angiogenesis Human Membrane Antibody Array (20 Targets) Target : Angiogenin, EGF, ENA-78, bFGF, GRO, IFN-gamma, IGF-I, IL-6, IL-8, Leptin, MCP-1, PDGF-BB, PIGF, RANTES, TGF-beta1, TIMP-1, TIMP-2, Thrombopoietin, VEGF-A, VEGF-D | ab134000 | |||||
Angiogenesis Human Membrane Antibody Array (23 targets) Target : Angiopoietin 1, Angiopoietin 2, Angiostatin, Endostatin, G-CSF, GM-CSF, I-309, IL-10, IL-1 alpha, IL-1 beta, IL-2, IL-4, I-TAC, MCP-3, MCP-4, MMP-1, MMP-9, PECAM-1, Tie-2, TNF alpha, uPAR, VEGFR2, VEGFR3 |
ab169808 | |||||
抗体アレイ一覧 |
製品名 | 交差種 | 容量 | 製品番号 | |||
---|---|---|---|---|---|---|
VEGF ELISA Kit | Ms | 1x96tests | ab209882 | |||
VEGF ELISA Kit | Hu | 1x96tests | ab100662 | |||
VEGF ELISA Kit | Rat | 1x96tests | ab100786 | |||
VEGF ELISA Kit | Ms | 1x96tests | ab100751 | |||
VEGF Receptor 1 ELISA Kit (FLT1) | Hu | 1x96tests | ab195210 | |||
VEGF Receptor 2 ELISA Kit | Hu | 1x96tests | ab213476 | |||
VEGF Receptor 3 ELISA Kit (FLT4) | Ms | 1x96tests | ab203367 | |||
キット一覧 |
製品名 | 解説 | 製品番号 | |||
---|---|---|---|---|---|
AAL-993 | Potent, selective and cell-permeable VEGFR inhibitor | ab141590 | |||
SU 6668 | Potent PDGFR inhibitor (IC50 = 60 nM). Also inhibits VEGFR2 and FGFR1 (IC50 values are 2 and 3 μM respectively). | ab142156 | |||
SU 1498 | Selective VEGFR2 inhibitor | ab141447 | |||
SU4312 | Potent, selective VEGFR and PDGFR receptor tyrosine kinase inhibitor | ab141577 | |||
VEGFR2 Kinase Inhibitor I | A highly selective, cell-permeable receptor tyrosine kinase (RTK) inhibitor (IC50 = 70 nM) for murine vascular endothelial growth factor receptor 2 (VEGF-R2; KDR/Flk-1). | ab145888 | |||
Royal jelly acid (10-Hydroxy-2-decenoic acid) | VEGF inhibitor | ab144050 | |||
SU-5402 | Potent, selective VEGFR and FGFR inhibitor | ab141368 |
製品名 | 適用・アプリケーション | 製品番号 | |
---|---|---|---|
VEGF 165A protein | Hu | CellAct, CellDiff, FuncS, SDS-PAGE | ab9571 |
VEGF protein | Hu | SDS-PAGE, WB | ab55566 |
VEGF Receptor 1 protein | Hu | FuncS, SDS-PAGE, WB | ab84771 |
VEGFC protein | Hu | SDS-PAGE | ab83573 |
VEGF Receptor 2 protein | Hu | FuncS, SDS-PAGE | ab106310 |
タンパク質・ペプチド一覧 |
5 種類のサブタイプと PIGF で VEGF ファミリーを形成している。また受容体は主に内皮細胞に存在し、VEGFR-1~3 の 3 種のチロシンキナーゼ型受容体と分泌型 VEGFR-1 および NRP-1 (ニューロピリン) が報告されている。
実験医学増刊 Vol.28 No.17 特集 「血管研究と血管治療」 (羊土社) より
Function 機能 | Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. | |||
組織特異性 | Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. | |||
疾患関連性 | Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1) [MIM:603933]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. | |||
配列類似性 | Belongs to the PDGF/VEGF growth factor family. | |||
Cellular localization 細胞内局在性 | Secreted. VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin. |
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