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ターゲット名 | 交差種 | 適用 | 文献数 | ||||||
---|---|---|---|---|---|---|---|---|---|
c-Myc | Hu, Ms, Rat | Flow Cyt, ICC/IF, IHC-P, IP, WB | 230 | ab32072 | |||||
c-Myc | Ms-M | Hu, Chk, Sc | ChIP, Flow Cyt, IHC-Fr, IHC-P, IP, WB | 29 | ab56 | ||||
c-Myc | Rb-P | Hu, Ms, Rat | ELISA, ICC/IF, IHC-FoFr, IHC-P, WB | 19 | ab39688 | ||||
c-Myc | Rat-M | Hu | IHC-Fr, IP, WB | 8 | ab10910 | ||||
抗体一覧 |
ターゲット名 | 交差種 | 適用 | 文献数 | |||||||
---|---|---|---|---|---|---|---|---|---|---|
c-Myc | Hu | WB | ab205818 | |||||||
c-Myc | Hu | ICC/IF | ab190026 | |||||||
c-Myc | Hu | ICC/IF | ab201780 | |||||||
c-Myc | Hu, Rat | ICC/IF | ab201781 | |||||||
c-Myc | Hu | ICC/IF | ab201775 | |||||||
c-Myc | Ms, Rat, Hu | ICC/IF | ab190560 | |||||||
抗体一覧 |
ターゲット名 | 交差種 | 適用 | 文献数 | ||||||
---|---|---|---|---|---|---|---|---|---|
c-Myc | Hu, Ms, Rat | Dot, Flow Cyt, ICC/IF, IHC-P, IP, WB | 3 | ab185656 | |||||
c-Myc | Rb-P | Hu, Ms, Rat | ELISA, ICC/IF, IHC-FoFr, IHC-P, WB | 19 | ab51156 | ||||
c-Myc | Rb-P | Hu | ELISA, ICC/IF, IHC-P, IP, WB | 7 | ab28842 | ||||
c-Myc | Hu | Flow Cyt, ICC/IF, WB | ab185655 | ||||||
c-Myc | Rb-P | Hu | ICC/IF, IHC-P, WB | ab131099 | |||||
c-Myc | Rb-P | Hu | IHC-P, WB | 1 | ab46848 | ||||
抗体一覧 |
ターゲット名 | 交差種 | 適用 | 文献数 | ||||||
---|---|---|---|---|---|---|---|---|---|
Myc tag | Ms-M | Ms, Hu | ChIP, ELISA, Flow Cyt, ICC, ICC/IF, IHC (Methanol fixed), IHC-Fr, IHC-P, IP, Purification, WB | 141 | ab32 | ||||
Myc tag | Ms-M | Hu | ELISA, IHC-Fr, IHC-P, WB | 17 | ab62928 | ||||
Myc tag | Rb-P | EM, Flow Cyt, ICC, ICC/IF, IHC-Fr, IHC-P, IP, WB | 216 | ab9106 | |||||
Myc tag | Goat-P | ChIP, ELISA, Flow Cyt, ICC, ICC/IF, IHC-Fr, IP, WB | 65 | ab9132 | |||||
Myc tag | Ms-M | Dot, ELISA, ICC/IF, IP, WB | 10 | ab18185 | |||||
Myc tag | Goat-P | ICC, ICC/IF | 6 | ab1263 | |||||
Tag 抗体一覧 |
免疫動物 | 非標識 | Agarose | Biotin | FITC | HRP |
---|---|---|---|---|---|
Chicken | ab172 | ab1394 | ab190058 | ||
Goat | ab9132 | ab1253 | ab1263 | ab1261 | |
Mouse | ab18185 | ab173829 | ab173829 | ||
Rabbit | ab9106 | ab34773 | ab1393 | ab1326 |
製品名 | 適用 | 製品番号 | |
---|---|---|---|
c-Myc protein | Hu | FuncS, SDS-PAGE, WB | ab84132 |
c-Myc protein(Active) | Hu | FuncS, MS, SDS-PAGE, WB | ab169901 |
c-Myc (mutated T73 A) protein(Active) | Hu | FuncS, SDS-PAGE | ab135024 |
タンパク質・ペプチド一覧 |
製品名 | 種交差性 | 感度 | 製品番号 | |||
---|---|---|---|---|---|---|
c-Myc Transcription Factor Assay Kit (Colorimetric) | Hu, Ms | < 250 ng/well(半定量) | ab207200 | |||
核抽出物サンプル中の c-Myc の、DNA 結合活性を定量するキットです。96 ウェルプレートを用いた ELISA 様フォーマットで、操作が簡単であり、またハイスループット解析にも適しています。マイクロプレートのウェルには c-Myc が結合するモチーフ 5'–CACGTG–3' を含む DNA オリゴヌクレオチドが固相化されています。その DNA に結合したサンプル中の c-Myc を、c-Myc 抗体で検出します。 |
製品名 | 生理活性 | 製品番号 | |||
---|---|---|---|---|---|
Cell-permeable c-Myc-Max dimerization inhibitor. Downregulates c-Myc expression and upregulates CDK inhibitors, p21 and p27. Inhibits proliferation. Induces apoptosis and cell cycle arrest in G0/G1 phase. Shows antitumor effects in vivo. | ab145065 |
c-Myc は細胞増殖の制御に深く関与している Myc ファミリーに属する転写因子で、癌で広く研究されている因子の一つですが、組み換えタンパク質発現の際のタグとしてもおなじみです。また、iPS 細胞作製における 4 つの因子のうちの一つとしてもよく知られるようになりました。
Function 機能 | Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes. | |||
Involvement in disease 疾患関連性 | Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1. Defects in MYC are a cause of Burkitt lymphoma (BL) [MIM:113970]. A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci. | |||
Sequence similarities 配列類似性 | Contains 1 basic helix-loop-helix (bHLH) domain. | |||
modifications 翻訳後修飾 | Phosphorylated by PRKDC. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome. Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28, due to the lack of interaction between isoform 4 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus. Also polyubiquitinated by the DCX(TRUSS) complex. | |||
Cellular localization 細胞内局在 | Nucleus > nucleoplasm. Nucleus > nucleolus. | |||
Alternative names 別名 | AU016757, Avian myelocytomatosis viral oncogene homolog, bHLHe39, Cellular myelocytomatosis oncogene, Cellular myelocytomatosis oncogene, Class E basic helix-loop-helix protein 39, MGC105490, MRTL, Myc proto oncogene protein, Myc-related translation/localization regulatory factor, MYC_HUMAN, Myc2, myca, Myelocytomatosis oncogene a, Myelocytomatosis oncogene, Niard, Nird, Oncogene Myc, OTTHUMP00000158589, OTTHUMP00000227763, Proto-oncogene c-Myc, Protooncogene homologous to myelocytomatosis virus, RNCMYC, Transcription factor p64, Transcriptional regulator Myc-A, v myc avian myelocytomatosis viral oncogene homolog |