Anti-COMP/Cartilage oligomeric matrix protein 抗体 [MA37C94 (HC484D1)] (ab11056)
Key features and details
- Rat monoclonal [MA37C94 (HC484D1)] to COMP/Cartilage oligomeric matrix protein
- Suitable for: ELISA, IHC-Fr, IHC-P, IP, WB
- Reacts with: Human
- Isotype: IgG2a
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-COMP/Cartilage oligomeric matrix protein antibody [MA37C94 (HC484D1)]
COMP/Cartilage oligomeric matrix protein 一次抗体 製品一覧 -
製品の詳細
Rat monoclonal [MA37C94 (HC484D1)] to COMP/Cartilage oligomeric matrix protein -
由来種
Rat -
特異性
Ab11056 recognises human COMP/Cartilage oligomeric matrix protein.
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アプリケーション
適用あり: ELISA, IHC-Fr, IHC-P, IP, WBmore details -
種交差性
交差種: Human -
免疫原
Full length native protein (purified) corresponding to Human COMP/Cartilage oligomeric matrix protein.
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エピトープ
The antibody recognises an epitope located in the central portion of the molecule. Unfortunately, we do not have information regarding the exact region. -
特記事項
Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.40
Preservative: 0.09% Sodium azide
Constituents: Tissue culture supernatant, PBS -
Concentration information loading... -
精製度
Protein G purified -
ポリ/モノ
モノクローナル -
クローン名
MA37C94 (HC484D1) -
ミエローマ
NS1 -
アイソタイプ
IgG2a -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab11056の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
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| IHC-Fr |
Use at an assay dependent concentration.
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| IHC-P | (2) |
Use at an assay dependent concentration.
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| IP |
Use at an assay dependent concentration.
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| WB |
Use at an assay dependent concentration.
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| 特記事項 |
|---|
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ELISA
Use at an assay dependent concentration. |
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IHC-Fr
Use at an assay dependent concentration. |
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IHC-P
Use at an assay dependent concentration. |
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IP
Use at an assay dependent concentration. |
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WB
Use at an assay dependent concentration. |
ターゲット情報
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機能
May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7. -
組織特異性
Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect. -
関連疾患
Defects in COMP are the cause of multiple epiphyseal dysplasia type 1 (EDM1) [MIM:132400]. EDM is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. EDM is broadly categorized into the more severe Fairbank and the milder Ribbing types.
Defects in COMP are the cause of pseudoachondroplasia (PSACH) [MIM:177170]. PSAC is a dominantly inherited chondrodysplasia characterized by short stature and early-onset osteoarthrosis. PSACH is more severe than EDM1 and is recognized in early childhood. -
配列類似性
Belongs to the thrombospondin family.
Contains 4 EGF-like domains.
Contains 1 TSP C-terminal (TSPC) domain.
Contains 8 TSP type-3 repeats. -
発生段階
Present during the earliest stages of limb maturation and is later found in regions where the joints develop. -
ドメイン
The cell attachment motif mediates the attachment to chondrocytes. It mediates the induction of both the IAP family of survival proteins and the antiapoptotic response.
The TSP C-terminal domain mediates interaction with FN1 and ACAN. -
細胞内局在
Secreted > extracellular space > extracellular matrix. - Information by UniProt
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参照データベース
- Entrez Gene: 1311 Human
- Omim: 600310 Human
- SwissProt: P49747 Human
- Unigene: 1584 Human
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別名
- cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) antibody
- Cartilage oligomeric matrix protein antibody
- Cartilage oligomeric matrix protein precursor antibody
see all
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (13)
ab11056 は 13 報の論文で使用されています。
- Zhang J et al. Cartilage oligomeric matrix protein affects the biological behavior of papillary thyroid carcinoma cells by activating the PI3K/AKT/Bcl-2 pathway. J Cancer 12:1623-1633 (2021). PubMed: 33613749
- Hecht JT et al. Resveratrol Reduces COMPopathy in Mice Through Activation of Autophagy. JBMR Plus 5:e10456 (2021). PubMed: 33778324
- Delaine-Smith RM et al. Modelling TGFßR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer. iScience 24:102674 (2021). PubMed: 34189438
- Malacrida B et al. A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion. iScience 24:102676 (2021). PubMed: 34189439
- Li Q et al. HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways. J Exp Clin Cancer Res 37:231 (2018). PubMed: 30231922
