Anti-COLQ 抗体 (ab127048)
Key features and details
- Rabbit polyclonal to COLQ
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-COLQ antibody -
製品の詳細
Rabbit polyclonal to COLQ -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Recombinant fragment, corresponding to a region within amino acids 248-420 of Human COLQ (UniProt Q9Y215).
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ポジティブ・コントロール
- HepG2 whole cell lysate, Human colon carcinoma tissue
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab127048の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 48 kDa.
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IHC-P |
1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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特記事項 |
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WB
1/500 - 1/3000. Predicted molecular weight: 48 kDa. |
IHC-P
1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ターゲット情報
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機能
Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina. -
組織特異性
Found at the end plate of skeletal muscle. -
関連疾患
Defects in COLQ are the cause of congenital myasthenic syndrome Engel type (CMSE) [MIM:603034]; also known as end-plate acetylcholinesterase deficiency or congenital myasthenic syndrome type IC (CMS-IC). CMSE is a rare autosomal recessive congenital myasthenic syndrome characterized by onset during childhood, generalized weakness, abnormal fatigability on exertion, refrectoriness to acetylcholinesterase drugs, decremental electromyographic response and morphological abnormalities of the neuromuscular junctions. -
配列類似性
Belongs to the COLQ family.
Contains 2 collagen-like domains. -
ドメイン
The proline-rich attachment domain (PRAD) binds the AChE catalytic subunits. -
翻訳後修飾
The triple-helical tail is stabilized by disulfide bonds at each end. -
細胞内局在
Cell junction > synapse. - Information by UniProt
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参照データベース
- Entrez Gene: 8292 Human
- Omim: 603033 Human
- SwissProt: Q9Y215 Human
- Unigene: 146735 Human
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別名
- Acetylcholinesterase collagen-like tail subunit isoform I antibody
- Acetylcholinesterase collagenic tail peptide antibody
- Acetylcholinesterase collagenic tail peptide precursor antibody
see all
画像
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Anti-COLQ antibody (ab127048) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg
Predicted band size: 48 kDa
10% SDS PAGE -
ab1267048, at a dilution of 1/500, staining COLQ in paraffin-embedded Human colon carcinoma tissue by Immunohistochemistry.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab127048 は論文での使用が確認できていません。