Anti-COL8A1 抗体 (ab58776)
Key features and details
- Rabbit polyclonal to COL8A1
- Suitable for: ELISA, WB
- Reacts with: Mouse
- Isotype: IgG
製品の概要
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製品名
Anti-COL8A1 antibody
COL8A1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to COL8A1 -
由来種
Rabbit -
アプリケーション
適用あり: ELISA, WBmore details -
種交差性
交差種: Mouse
交差が予測される動物種: Rabbit, Human -
免疫原
Synthetic peptide corresponding to Human COL8A1 (C terminal).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab58776の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ELISA |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
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特記事項 |
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ELISA
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
ターゲット情報
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機能
Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in artherogenesis.
Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis. -
組織特異性
Expressed primarily in the subendothelium of large blood vessels. Also expressed in arterioles and venules in muscle, heart, kidney, spleen, umbilical cord, liver and lung and is also found in connective tissue layers around hair follicles, around nerve bundles in muscle, in the dura of the optic nerve, in cornea and sclera, and in the perichondrium of cartilaginous tissues. In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells. Also expressed in mast cells, and in astrocytes during the repair process. Expressed in Descemet's membrane. Specifically expressed in peritoneal fibroblasts and mesothelial cells. -
配列類似性
Contains 1 C1q domain. -
翻訳後修飾
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Proteolytically cleaved by neutrophil elastase, in vitro. Proteolytic processing produces the C-terminal NC1 domain fragment, vastatin. -
細胞内局在
Secreted > extracellular space > extracellular matrix > basement membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 1295 Human
- Entrez Gene: 12837 Mouse
- Entrez Gene: 100009383 Rabbit
- Omim: 120251 Human
- SwissProt: P27658 Human
- SwissProt: Q00780 Mouse
- SwissProt: P14282 Rabbit
- Unigene: 654548 Human
see all -
別名
- C3orf7 antibody
- CO8A1_HUMAN antibody
- COL8A1 antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (5)
ab58776 は 5 報の論文で使用されています。
- Guo W et al. Screening and bioinformatical analysis of differentially expressed genes in nasopharyngeal carcinoma. J Cancer 12:1867-1883 (2021). PubMed: 33753985
- Ma ZH et al. Effect of enhanced expression of COL8A1 on lymphatic metastasis of hepatocellular carcinoma in mice. Exp Ther Med 4:621-626 (2012). WB . PubMed: 23170115
- Loeffler I et al. Type VIII Collagen Modulates TGF-{beta}1-induced Proliferation of Mesangial Cells. J Am Soc Nephrol 22:649-63 (2011). WB ; Mouse . PubMed: 21372207
- Todorovic V et al. Detection of differentially expressed basal cell proteins by mass spectrometry. Mol Cell Proteomics 9:351-61 (2010). WB ; Mouse . PubMed: 19955077
- Zhao Y et al. siRNA-targeted COL8A1 inhibits proliferation, reduces invasion and enhances sensitivity to D-limonence treatment in hepatocarcinoma cells. IUBMB Life 61:74-9 (2009). WB ; Mouse . PubMed: 19109829