CNQX disodium salt, AMPA / kainate antagonist (ab120044)
Key features and details
- AMPA / kainate antagonist; water soluble
- CAS Number: 479347-85-8
- Soluble in water to 25 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
CNQX disodium salt, AMPA / kainate antagonist -
製品の詳細
AMPA / kainate antagonist; water soluble -
生理活性の詳細
Water soluble, potent, competitive AMPA / kainate receptor antagonist. Also antagonist at NMDA receptor glycine site.
Also available in simple stock solutions (ab144488) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS 番号
479347-85-8 -
構造式
製品の特性
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体系名
1,2,3,4-Tetrahydro-7-nitro-2,3-dioxoquinoxaline-6-carbonitrile disodium -
分子量
276.12 -
分子式
C9H2N4Na2O4 -
PubChem 登録番号
2821 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 25 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
[Na+].[Na+].[O-][N+](=O)c1cc2nc([O-])c([O-])nc2cc1C#N -
由来
Synthetic
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研究分野
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab120044の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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Functional Studies |
Use at an assay dependent concentration.
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特記事項 |
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Functional Studies
Use at an assay dependent concentration. |
画像
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2D chemical structure image of ab120044, CNQX disodium salt, AMPA / kainate antagonist
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ab96379 staining MEK1 (phospho S298) in SK-N-SH cells treated with CNQX disodium salt (ab120044), by ICC/IF. Decrease in MEK1 (phospho S298) expression correlates with increased concentration of CNQX disodium salt, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120044 (CNQX disodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab96379 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (35)
ab120044 は 35 報の論文で使用されています。
- Katada Y et al. Starburst amacrine cells amplify optogenetic visual restoration through gap junctions. Mol Ther Methods Clin Dev 30:1-13 (2023). PubMed: 37324975
- Bonnycastle K et al. Reversal of cell, circuit and seizure phenotypes in a mouse model of DNM1 epileptic encephalopathy. Nat Commun 14:5285 (2023). PubMed: 37648685
- Wei XP et al. A novel reticular node in the brainstem synchronizes neonatal mouse crying with breathing. Neuron 110:644-657.e6 (2022). PubMed: 34998469
- Bonnycastle K et al. FMRP Sustains Presynaptic Function via Control of Activity-Dependent Bulk Endocytosis. J Neurosci 42:1618-1628 (2022). PubMed: 34996816
- Mishra P & Narayanan R Conjunctive changes in multiple ion channels mediate activity-dependent intrinsic plasticity in hippocampal granule cells. iScience 25:103922 (2022). PubMed: 35252816