cis-PPDA, GluN2C/GluN2D NMDA antagonist (ab120047)
Key features and details
- GluN2C/GluN2D (formerly NR2C/NR2D) NMDA antagonist
- CAS Number: 684283-16-7
- Soluble in 2 eq. NaOH to 50 mM (with warming)
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
cis-PPDA, GluN2C/GluN2D NMDA antagonist -
製品の詳細
GluN2C/GluN2D (formerly NR2C/NR2D) NMDA antagonist -
生理活性の詳細
Potent GluN2C/GluN2D (formerly NR2C / NR2D)-preferring NMDA receptor antagonist. (Ki values for recombinant rat receptors are 0.096 (NR2C), 0.125 (NR2D), 0.55 (NR2A) and 0.31 μM (NR2B)).
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CAS 番号
684283-16-7 -
構造式
製品の特性
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体系名
(2R*,3S*)-1-(Phenanthrenyl-2-carbonyl)piperazine-2,3-dicarboxylic acid -
分子量
378.38 -
分子式
C21H18N2O5 -
PubChem 登録番号
10293029 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in 2 eq. NaOH to 50 mM (with warming) -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
O=C(c2cc3ccc1ccccc1c3cc2)N4CCNC(C(=O)O)C4C(=O)O -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (5)
ab120047 は 5 報の論文で使用されています。
- Doyle S et al. Vesicular glutamate release from central axons contributes to myelin damage. Nat Commun 9:1032 (2018). PubMed: 29531223
- Zhang Z & Sun QQ Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons. Dev Neurobiol 71:221-45 (2011). PubMed: 20936660
- Sun QQ & Zhang Z Whisker experience modulates long-term depression in neocortical ?-aminobutyric acidergic interneurons in barrel cortex. J Neurosci Res 89:73-85 (2011). PubMed: 21046566
- Pregno G et al. Neuregulin1/ErbB4-induced migration in ST14A striatal progenitors: calcium-dependent mechanisms and modulation by NMDA receptor activation. BMC Neurosci 12:103 (2011). PubMed: 21991932
- Harney SC et al. Extrasynaptic NR2D-containing NMDARs are recruited to the synapse during LTP of NMDAR-EPSCs. J Neurosci 28:11685-94 (2008). PubMed: 18987204