Anti-CHRDL1 抗体 (ab103369)
Key features and details
- Rabbit polyclonal to CHRDL1
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
製品の概要
-
製品名
Anti-CHRDL1 antibody
CHRDL1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to CHRDL1 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Human -
免疫原
Recombinant full length protein, corresponding to amino acids 1-450 of Human CHRDL1 (ENSP00000361115)
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.4
Constituent: PBS -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab103369の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/500 - 1/1000. Predicted molecular weight: 51 kDa.
|
| 特記事項 |
|---|
|
WB
1/500 - 1/1000. Predicted molecular weight: 51 kDa. |
ターゲット情報
-
機能
Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embyonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis trough modulation of BMP4 actions in endothelial cells. -
組織特異性
Expressed in retinal pericytes. -
配列類似性
Contains 3 VWFC domains. -
細胞内局在
Secreted. - Information by UniProt
-
参照データベース
- Entrez Gene: 91851 Human
- Entrez Gene: 83453 Mouse
- Omim: 300350 Human
- SwissProt: Q9BU40 Human
- SwissProt: Q920C1 Mouse
- Unigene: 496587 Human
-
別名
- CHL antibody
- chordin like 1 antibody
- Chordin-like protein 1 antibody
see all
画像
-
Western blot - Anti-CHRDL1 antibody (ab103369)Anti-CHRDL1 antibody (ab103369) at 1/500 dilution + Mouse kidney tissue lysate
Predicted band size: 51 kDa -
Western blot - Anti-CHRDL1 antibody (ab103369)All lanes : Anti-CHRDL1 antibody (ab103369) at 1/500 dilution
Lane 1 : CHRDL1 transfected 293T cell lysate
Lane 2 : 293T non-transfected cell lysate
Predicted band size: 51 kDa
データシートおよび資料
-
Datasheet download
参考文献 (2)
ab103369 は 2 報の論文で使用されています。
- Liu T et al. Chordin-Like 1 Improves Osteogenesis of Bone Marrow Mesenchymal Stem Cells Through Enhancing BMP4-SMAD Pathway. Front Endocrinol (Lausanne) 10:360 (2019). PubMed: 31249554
- Cyr-Depauw C et al. Chordin-Like 1 Suppresses Bone Morphogenetic Protein 4-Induced Breast Cancer Cell Migration and Invasion. Mol Cell Biol 36:1509-25 (2016). PubMed: 26976638
