Charybdotoxin, K+ channel blocker (ab120269)
Key features and details
- K+ channel blocker
- CAS Number: 95751-30-7
- Soluble in water
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Charybdotoxin, K+ channel blocker -
製品の詳細
K+ channel blocker -
生理活性の詳細
Blocks KCa1.1 (large conductance Ca2+ activated K+, Slo) channels in nanomolar concentrations as well as Kv1.2 (Kd = 14 nM) and Kv1.3 (Kd = 2.6 nM) channels.
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CAS 番号
95751-30-7 -
構造式
製品の特性
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分子量
4295.89 -
分子式
C176H277N57O55S7 -
配列
XFTNVSCTTSKECWSVCQRLHNTSRGKCMNKKCRCYS (Modifications: X-1 = Glp; Disulfide bonds: 7-28, 13-33, 17-35) -
PubChem 登録番号
56842037 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (4)
ab120269 は 4 報の論文で使用されています。
- Jonusaite S et al. Tissue-specific ionomotive enzyme activity and K+ reabsorption reveal the rectum as an important ionoregulatory organ in larval Chironomus riparius exposed to varying salinity. J Exp Biol 216:3637-48 (2013). PubMed: 23788699
- Zhang J et al. Role of the BK channel (KCa1.1) during activation of electrogenic K+ secretion in guinea pig distal colon. Am J Physiol Gastrointest Liver Physiol 303:G1322-34 (2012). PubMed: 23064759
- Farrell SR et al. Modulation of voltage-gated ion channels in rat retinal ganglion cells mediated by somatostatin receptor subtype 4. J Neurophysiol 104:1347-54 (2010). PubMed: 20573967
- Yang H & Xu-Friedman MA Developmental mechanisms for suppressing the effects of delayed release at the endbulb of Held. J Neurosci 30:11466-75 (2010). PubMed: 20739568