製品の概要

  • 製品名

    CGP 55845 hydrochloride, GABAB antagonist
  • 製品の詳細

    Potent, selective GABAB antagonist
  • 別名

    • CGP55845 hydrochloride
  • 生理活性の詳細

    Potent, selective GABAB antagonist (IC50 = 5 nM). Prevents agonist binding (pKi = 8.35) and blocks GABAB responses to Baclofen (ab120325). Inhibits GABA and glutamate release (pEC50 values are 8.08 and 7.85, respectively). Stimulates glucose induced insulin secretion.

  • 精製度

    > 99%
  • CAS 番号

    149184-22-5
  • 構造式

    Chemical Structure

製品の特性

画像

  • 5-CT-activated inwardly rectifying K+ conductance in 5-HT neurons displays limited desensitization.

    (A) Time-course of a representative experiment (n = 6) showing the effect of increasing concentrations of bath applied 5-HT1A receptor agonist, 5-CT on inwardly rectifying K+ conductance (G-110/-90 mV) in a dorsal raphe 5-HT neuron. Extracellular solution contained 5.5 mM K+ and a mix of synaptic blockers (including ab120337). In this Fig time indicates duration of whole-cell configuration.

参考文献

This product has been referenced in:

  • Salah A & Perkins KL Effects of subtype-selective group I mGluR antagonists on synchronous activity induced by 4-aminopyridine/CGP 55845 in adult guinea pig hippocampal slices. Neuropharmacology 55:47-54 (2008). Read more (PubMed: 18538357) »
  • Braun M  et al. GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin. J Physiol 559:397-409 (2004). Read more (PubMed: 15235087) »
  • Vinay L & Clarac F CGP 35348 and CGP 55845A block the baclofen-induced depression of dorsal root evoked potentials in lumbar motoneurons of the neonatal rat. Neurosci Lett 214:103-6 (1996). Read more (PubMed: 8878094) »
  • Waldmeier PC  et al. GABA and glutamate release affected by GABAB receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors. Br J Pharmacol 113:1515-21 (1994). Read more (PubMed: 7889310) »
See all 17 Publications for this product

レビューと Q&A

Answer

Thank you for contacting us.


As discussed over the phone the solubility of CGP 55845 hydrochloride is 100 mM in DMSO. The information on the CoA was unfortunately an error. Thank you for bringing this to our attention. This will be altered to reflect the correct information.


I hope this information has been of help. If you require any further information please do nothesitate to contact us again.

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