CGP 52432, GABAB antagonist (ab120330)
Key features and details
- Potent GABAB antagonist
- CAS Number: 139667-74-6
- Soluble in water to 10 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
CGP 52432, GABAB antagonist -
製品の詳細
Potent GABAB antagonist -
生理活性の詳細
Potent, selective GABAB antagonist (IC50 = 85 nM).
Also available in simple stock solutions (ab146709) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS 番号
139667-74-6 -
構造式
製品の特性
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体系名
3-[[(3,4-Dichlorophenyl)methyl]amino]propyl(diethoxymethyl)phosphinic acid -
分子量
384.24 -
分子式
C15H24Cl2NO4P -
PubChem 登録番号
132252 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 10 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Clc1ccc(CNCCCP(=O)(O)C(OCC)OCC)cc1Cl -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (10)
ab120330 は 10 報の論文で使用されています。
- Dorgans K et al. Short-term plasticity at cerebellar granule cell to molecular layer interneuron synapses expands information processing. Elife 8:N/A (2019). PubMed: 31081751
- Kim S et al. Dendritic spikes in hippocampal granule cells are necessary for long-term potentiation at the perforant path synapse. Elife 7:N/A (2018). PubMed: 29578411
- Minge D et al. Heparan Sulfates Support Pyramidal Cell Excitability, Synaptic Plasticity, and Context Discrimination. Cereb Cortex 27:903-918 (2017). PubMed: 28119345
- Schauer C et al. Hypothalamic gonadotropin-releasing hormone (GnRH) receptor neurons fire in synchrony with the female reproductive cycle. J Neurophysiol 114:1008-21 (2015). PubMed: 26063780
- Hernández VM et al. Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus. J Neurosci 35:11830-47 (2015). PubMed: 26311767
- Hedrick T & Waters J Acetylcholine excites neocortical pyramidal neurons via nicotinic receptors. J Neurophysiol 113:2195-209 (2015). PubMed: 25589590
- Russo G et al. Dynamics of action potential firing in electrically connected striatal fast-spiking interneurons. Front Cell Neurosci 7:209 (2013). PubMed: 24294191
- Valera AM et al. Adaptation of granule cell to Purkinje cell synapses to high-frequency transmission. J Neurosci 32:3267-80 (2012). PubMed: 22378898
- Min R & Nevian T Astrocyte signaling controls spike timing-dependent depression at neocortical synapses. Nat Neurosci 15:746-53 (2012). PubMed: 22446881
- Brager DH et al. Impaired dendritic expression and plasticity of h-channels in the fmr1(-/y) mouse model of fragile X syndrome. Cell Rep 1:225-33 (2012). PubMed: 22662315