CGP 37157, Na+-Ca2+ exchange inhibitor (ab120012)
Key features and details
- Na+-Ca2+ exchange inhibitor
- CAS Number: 75450-34-9
- Soluble in water to 5 mM, in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
CGP 37157, Na+-Ca2+ exchange inhibitor -
製品の詳細
Na+-Ca2+ exchange inhibitor -
生理活性の詳細
Selective inhibitor of the mitochondrial Na+-Ca2+ exchanger (IC50 = 0.4 μM).
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CAS 番号
75450-34-9 -
構造式
製品の特性
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体系名
7-Chloro-5-(2-chlorophenyl)-1,2,3,5-tetrahydro-4,1-benzothiazepin-2-one -
分子量
324.22 -
分子式
C15H11Cl2NOS -
PubChem 登録番号
2688 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 5 mM, in ethanol to 100 mM and in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Clc3ccccc3C1SCC(=O)Nc2ccc(Cl)cc12 -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (5)
ab120012 は 5 報の論文で使用されています。
- Wei K et al. Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1. Signal Transduct Target Ther 8:22 (2023). PubMed: 36658134
- Agarwal A et al. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron 93:587-605.e7 (2017). PubMed: 28132831
- Bondarenko AI et al. Characterization of distinct single-channel properties of Ca(2+) inward currents in mitochondria. Pflugers Arch : (2013). PubMed: 23397170
- Parnis J et al. Mitochondrial exchanger NCLX plays a major role in the intracellular Ca2+ signaling, gliotransmission, and proliferation of astrocytes. J Neurosci 33:7206-19 (2013). PubMed: 23616530
- Jean-Quartier C et al. Studying mitochondrial Ca(2+) uptake - a revisit. Mol Cell Endocrinol 353:114-27 (2012). PubMed: 22100614