Anti-CD8 alpha 抗体 [IBL-3/25] (ab3081)

Submit a review Q&A (1)References (4)

Key features and details

  • Rat monoclonal [IBL-3/25] to CD8 alpha
  • Suitable for: Flow Cyt, IHC-Fr, IP
  • Reacts with: Mouse
  • Isotype: IgG1

製品の概要

  • 製品名

    Anti-CD8 alpha antibody [IBL-3/25]
    CD8 alpha 一次抗体 製品一覧

  • 製品の詳細

    Rat monoclonal [IBL-3/25] to CD8 alpha

  • 由来種

    Rat

  • アプリケーション

    適用あり: Flow Cyt, IHC-Fr, IPmore details

  • 種交差性

    交差種: Mouse

  • 免疫原

    Mouse spleen cells.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab3081 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use a concentration of 1 - 10 µg/ml.

ab18407 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody.

 
IHC-Fr Use a concentration of 1 - 10 µg/ml. acetone fixed.
IP Use a concentration of 1 - 10 µg/ml.

ターゲット情報

  • 機能

    Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.

  • 関連疾患

    Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.

  • 配列類似性

    Contains 1 Ig-like V-type (immunoglobulin-like) domain.

  • 翻訳後修飾

    All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not.

  • 細胞内局在

    Secreted and Cell membrane.
  • Information by UniProt

  • 参照データベース

    • 別名

      • alpha polypeptide (p32) antibody
      • CD_antigen=CD8a antibody
      • CD8 antibody
      • CD8 antigen alpha polypeptide antibody
      • CD8 antigen alpha polypeptide (p32) antibody
      • CD8 antigen, alpha polypeptide (p32) antibody
      • CD8a antibody
      • CD8A antigen antibody
      • CD8A molecule antibody
      • CD8A_HUMAN antibody
      • Leu2 antibody
      • Leu2 T lymphocyte antigen antibody
      • Ly 2 antibody
      • Ly 35 antibody
      • Ly B antibody
      • Ly2 antibody
      • Ly3 antibody
      • Ly35 antibody
      • LyB antibody
      • Lyt 2.1 lymphocyte differentiation antigen (AA at 100) antibody
      • LYT3 antibody
      • MAL antibody
      • OKT8 T cell antigen antibody
      • OTTHUMP00000160760 antibody
      • OTTHUMP00000160764 antibody
      • OTTHUMP00000203528 antibody
      • OTTHUMP00000203721 antibody
      • p32 antibody
      • T cell antigen Leu2 antibody
      • T cell co receptor antibody
      • T lymphocyte differentiation antigen T8/Leu 2 antibody
      • T-cell surface glycoprotein CD8 alpha chain antibody
      • T-cell surface glycoprotein Lyt 2 antibody
      • T-lymphocyte differentiation antigen T8/Leu-2 antibody
      • T8 T cell antigen antibody
      • T8/Leu-2 T-lymphocyte differentiation antigen antibody
      see all

    参考文献 (4)

    ab3081 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab3081 は 4 報の論文で使用されています。

    • Draghiciu O  et al. Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication. Oncoimmunology 4:e989764 (2015). IHC ; Mouse . PubMed: 25949902
    • Gao X  et al. Role of donor and host cells in muscle-derived stem cell-mediated bone repair: differentiation vs. paracrine effects. FASEB J 28:3792-809 (2014). PubMed: 24843069
    • Kersting S  et al. The impact of JNK inhibitor D-JNKI-1 in a murine model of chronic colitis induced by dextran sulfate sodium. J Inflamm Res 6:71-81 (2013). IHC-FoFr ; Mouse . PubMed: 23667316
    • Kotakadi VS  et al. Ginkgo biloba extract EGb 761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosis. Carcinogenesis 29:1799-806 (2008). IHC-P ; Mouse . PubMed: 18567620

    レビューと Q&A

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    Question

    Dear abcam support desk, Thankyou so much for your fast response. I’mwondering if you still sell this item ab52854 because this antibody works great onour mouse section. Ifnot, do you have any recommendation? Let me know. Thank You for your help.  

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    Answer

    Thank you for contacting us. We have many other products that works well on mouse tissues and are fully tested. The catalogue numbers are Un conjugated anti CD8 antibodies ab22378 ab25478 ab3081 ab108292 Conjugated anti CD8 antibodies ab25294 ab25676 ab60077 ab25499 ab25498 ab39853 These antibodies will work on mouse section in the applications as recommended on datasheet. Please check the datasheets and buy the antibody as per your requirements. All antibodies are equally good and are fully guaranteed under Abpromise to work with mouse samples. I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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