製品の概要
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製品名Anti-CD68 antibody [PG-M1]
CD68 一次抗体 製品一覧 -
製品の詳細Mouse monoclonal [PG-M1] to CD68
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由来種Mouse
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アプリケーション適用あり: IHC-Pmore details
適用なし: ICC or IHC-Fr -
種交差性交差種: Human
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免疫原
Gaucher cells
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ポジティブ･コントロール
- IHC-P: Human tonsil and granulomatous inflammatory tissues.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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バッファーPreservative: 0.05% Sodium azide
Constituents: Tissue culture supernatant, 1% BSA -
精製度Tissue culture supernatant
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ポリ/モノモノクローナル
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クローン名PG-M1
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アイソタイプIgG3
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軽鎖の種類kappa
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研究分野
関連製品
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Alternative Versions
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Compatible Secondaries
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Recombinant Protein
アプリケーション
Our Abpromise guarantee covers the use of ab783 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P | 1/10 - 1/40. Perform enzymatic antigen retrieval before commencing with IHC staining protocol. (use ABC method). We suggest an incubation period of 30-60 minutes at room temperature. |
追加情報
Is unsuitable for ICC or IHC-Fr.
ターゲット情報
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機能Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
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組織特異性Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.
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配列類似性Belongs to the LAMP family.
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翻訳後修飾N- and O-glycosylated.
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細胞内局在Cell membrane and Endosome membrane. Lysosome membrane.
- Information by UniProt
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参照データベース
- Entrez Gene: 968 Human
- Omim: 153634 Human
- SwissProt: P34810 Human
- Unigene: 647419 Human
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別名
- CD 68 antibody
- CD68 antibody
- CD68 antigen antibody
see all
画像
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![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD68 antibody [PG-M1] (ab783)](https://www.abcam.co.jp/ps/products/0/ab783/Images/ab783-289954-CD68PGM1.jpg)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD68 antibody [PG-M1] (ab783)ab783 staining CD68 in Human tonsil tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections).
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![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD68 antibody [PG-M1] (ab783)](https://www.abcam.co.jp/ps/products/0/ab783/Images/ab783-291423-ab78311485.jpg)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD68 antibody [PG-M1] (ab783)This image is courtesy of an anonymous Abreview.Paraformaldehyde-fixed, paraffin-embedded human granulomatous inflammatory tissue stained for CD68 using ab783 in immunohistochemical analysis.
参考文献
This product has been referenced in:
- Hultman K et al. The APOE ?4/?4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients. J Cereb Blood Flow Metab 33:1251-8 (2013). Read more (PubMed: 23652625) »
- Horny HP et al. Immunoreactivity of normal and neoplastic human tissue mast cells with macrophage-associated antibodies, with special reference to the recently developed monoclonal antibody PG-M1. Hum Pathol 24:355-8 (1993). Read more (PubMed: 8491475) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"