保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
バッファーPreservative: 0.05% Sodium azide
Constituents: Tissue culture supernatant, 1% BSA
精製度Tissue culture supernatant
Our Abpromise guarantee covers the use of ab755 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use at an assay dependent concentration.
1/10 - 1/25 for 30 - 60 mins (ABC method).
|IHC-Fr||Use at an assay dependent concentration.|
機能Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.
関連疾患Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive
配列類似性Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
Contains 2 fibronectin type-III domains.
Contains 2 tyrosine-protein phosphatase domains.
ドメインThe first PTPase domain interacts with SKAP1.
翻訳後修飾Heavily N- and O-glycosylated.
細胞内局在Membrane. Membrane raft. Colocalized with DPP4 in membrane rafts.
- Information by UniProt
- B220 antibody
- CD45 antibody
- CD45 antigen antibody
ab755 has not yet been referenced specifically in any publications.