PE/Cy7® Anti-CD41 抗体 [MEM-06] (ab239313)
Key features and details
- PE/Cy7® Mouse monoclonal [MEM-06] to CD41
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: PE/Cy7®. Ex: 496nm, Em: 774nm
- Isotype: IgG1
Related conjugates and formulations
製品の概要
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製品名
PE/Cy7® Anti-CD41 antibody [MEM-06]
CD41 一次抗体 製品一覧 -
製品の詳細
PE/Cy7® Mouse monoclonal [MEM-06] to CD41 -
由来種
Mouse -
標識
PE/Cy7®. Ex: 496nm, Em: 774nm -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Human -
免疫原
Tissue, cells or virus corresponding to Human CD41. (Leukocytes of patient suffering from LGL-type leukaemia).
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ポジティブ・コントロール
- Flow Cyt: Human peripheral blood.
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特記事項
This product or portions thereof is manufactured under license from Carnegie Mellon University under U.S. Patent Number 5, 268, 486 and related patents. Cy® and CyDye® are trademarks of Cytiva.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. Store In the Dark. -
バッファー
pH: 7.4
Preservative: 0.0975% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Size exclusion -
特記事項(精製)
Purified antibody is conjugated with tandem dye PE/Cy7 ® under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. -
ポリ/モノ
モノクローナル -
クローン名
MEM-06 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Alternative Versions
- PE Anti-CD41 antibody [MEM-06], prediluted (ab134372)
- PerCP Anti-CD41 antibody [MEM-06], prediluted (ab134373)
- FITC Anti-CD41 antibody [MEM-06] (ab21851)
- Anti-CD41 antibody [MEM-06] (ab2211)
- PE/Cy5® Anti-CD41 antibody [MEM-06] (ab233450)
- Alexa Fluor® 700 Anti-CD41 antibody [MEM-06] (ab270670)
- Biotin Anti-CD41 antibody [MEM-06] (ab28065)
- APC Anti-CD41 antibody [MEM-06] (ab55866)
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab239313の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
Flow Cyt |
Use 4µl for 106 cells.
(or 100 µl of whole blood). |
特記事項 |
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Flow Cyt
Use 4µl for 106 cells. (or 100 µl of whole blood). |
ターゲット情報
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機能
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. -
組織特異性
Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells. -
関連疾患
Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors. -
配列類似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 3674 Human
- Omim: 607759 Human
- SwissProt: P08514 Human
- Unigene: 411312 Human
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別名
- antigen CD41 antibody
- BDPLT16 antibody
- BDPLT2 antibody
see all
画像
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (0)
ab239313 は論文での使用が確認できていません。