PerCP Anti-CD33 抗体 [WM53] (ab124531)
Key features and details
- PerCP Mouse monoclonal [WM53] to CD33
- Suitable for: Flow Cyt
- Reacts with: Human, Non human primates
- Conjugation: PerCP. Ex: 482nm, Em: 675nm
- Isotype: IgG1
Related conjugates and formulations
製品の概要
-
製品名
PerCP Anti-CD33 antibody [WM53]
CD33 一次抗体 製品一覧 -
製品の詳細
PerCP Mouse monoclonal [WM53] to CD33 -
由来種
Mouse -
標識
PerCP. Ex: 482nm, Em: 675nm -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Human, Non human primates -
免疫原
Tissue, cells or virus corresponding to Human CD33. Human AML cells.
-
ポジティブ・コントロール
- Human blood cells
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS, 0.2% BSA -
Concentration information loading...
-
精製度
Size exclusion -
ポリ/モノ
モノクローナル -
クローン名
WM53 -
アイソタイプ
IgG1 -
研究分野
関連製品
-
Alternative Versions
- APC Anti-CD33 antibody [WM53] (ab118967)
- APC/Cy7® Anti-CD33 antibody [WM53] (ab206634)
- Anti-CD33 antibody [WM53] - BSA and Azide free (ab213050)
- PE/Cy5® Anti-CD33 antibody [WM53] (ab233448)
- PE Anti-CD33 antibody [WM53] (ab233577)
- FITC Anti-CD33 antibody [WM53] (ab234216)
- PE/Cy7® Anti-CD33 antibody [WM53] (ab239310)
- Anti-CD33 antibody [WM53] - BSA and Azide free (ab252263)
- Alexa Fluor® 700 Anti-CD33 antibody [WM53] (ab269306)
- Anti-CD33 antibody [WM53] (ab30371)
-
Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab124531の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
Flow Cyt |
Use 10µl for 106 cells.
10 μl reagent / 100 μl of whole blood |
特記事項 |
---|
Flow Cyt
Use 10µl for 106 cells. 10 μl reagent / 100 μl of whole blood |
ターゲット情報
-
機能
Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). -
組織特異性
Monocytic/myeloid lineage cells. -
配列類似性
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
ドメイン
Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. -
翻訳後修飾
Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6. -
細胞内局在
Cell membrane. - Information by UniProt
-
参照データベース
- Entrez Gene: 945 Human
- Omim: 159590 Human
- SwissProt: P20138 Human
- Unigene: 83731 Human
-
別名
- CD 33 antibody
- CD33 antibody
- CD33 antigen (gp67) antibody
see all
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (7)
ab124531 は 7 報の論文で使用されています。
- Hernández-Caselles T et al. A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing. J Leukoc Biol 79:46-58 (2006). PubMed: 16380601
- Garnache-Ottou F et al. Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells. Blood 105:1256-64 (2005). PubMed: 15388576
- Schenk M et al. Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine. J Immunol 174:517-24 (2005). PubMed: 15611278
- Leone AM et al. Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function. Eur Heart J 26:1196-204 (2005). PubMed: 15734770
- Hernández-López C et al. Stromal cell-derived factor 1/CXCR4 signaling is critical for early human T-cell development. Blood 99:546-54 (2002). PubMed: 11781237
- Vitale C et al. Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: engagement of CD33 induces apoptosis of leukemic cells. Proc Natl Acad Sci U S A 98:5764-9 (2001). PubMed: 11320212
- Shin YK et al. Expression of leukemia-associated antigen, JL1, in bone marrow and thymus. Am J Pathol 158:1473-80 (2001). PubMed: 11290565