Anti-CD3 抗体 [UCH-T1] (ab22)

Submit a review Q&A (4)References (5)

Key features and details

  • Mouse monoclonal [UCH-T1] to CD3
  • Reacts with: Human
  • Isotype: IgG1

製品の概要

  • 製品名

    Anti-CD3 antibody [UCH-T1]
    CD3 一次抗体 製品一覧

  • 製品の詳細

    Mouse monoclonal [UCH-T1] to CD3

  • 由来種

    Mouse

  • 種交差性

    交差種: Human

  • 免疫原

    Tissue, cells or virus corresponding to Human CD3. Human infant thymocytes and Sezary cells

  • エピトープ

    Epsilon-chain

  • 特記事項

    Use: Enrichment of T cell populations by cell sorting or panning.

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

製品の特性

アプリケーション

追加情報
Is unsuitable for IHC-P.

ターゲット情報

  • 機能

    The CD3 complex mediates signal transduction.

  • 関連疾患

    Defects in CD3D are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)/B(+)/NK(+) SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.

  • 配列類似性

    Contains 1 ITAM domain.

  • 細胞内局在

    Membrane.
  • Information by UniProt

  • 参照データベース

    see all

  • 別名

    • 4930549J05Rik antibody
    • A430104F18Rik antibody
    • AW552088 antibody
    • Cd247 antibody
    • CD247 antigen antibody
    • CD247 antigen, zeta subunit antibody
    • CD247 molecule antibody
    • CD3 antibody
    • CD3 antigen, delta subunit antibody
    • CD3 delta antibody
    • CD3 epsilon antibody
    • CD3 eta antibody
    • CD3 gamma antibody
    • CD3 molecule delta polypeptide antibody
    • CD3 molecule, epsilon polypeptide antibody
    • CD3 molecule, gamma polypeptide antibody
    • CD3 zeta antibody
    • CD3-DELTA antibody
    • CD3d antibody
    • CD3D antigen delta polypeptide antibody
    • CD3d antigen, delta polypeptide (TiT3 complex) antibody
    • CD3d molecule delta antibody
    • CD3d molecule delta CD3 TCR complex antibody
    • CD3d molecule, delta (CD3-TCR complex) antibody
    • CD3D_HUMAN antibody
    • CD3E antibody
    • CD3e antigen antibody
    • CD3E antigen epsilon polypeptide antibody
    • CD3e antigen, epsilon polypeptide (TiT3 complex) antibody
    • CD3e molecule epsilon antibody
    • CD3e molecule epsilon CD3 TCR complex antibody
    • CD3e molecule, epsilon (CD3-TCR complex) antibody
    • CD3epsilon antibody
    • CD3G antibody
    • CD3g antigen antibody
    • CD3G antigen gamma polypeptide antibody
    • CD3g antigen, gamma polypeptide (TiT3 complex) antibody
    • CD3g molecule gamma antibody
    • CD3g molecule gamma CD3 TCR complex antibody
    • CD3g molecule, gamma (CD3-TCR complex) antibody
    • CD3H antibody
    • CD3Q antibody
    • CD3Z antibody
    • CD3zeta antibody
    • Ctg3 antibody
    • FLJ17620 antibody
    • FLJ17664 antibody
    • FLJ18683 antibody
    • FLJ79544 antibody
    • FLJ94613 antibody
    • IMD19 antibody
    • Leu-4 antibody
    • MGC138597 antibody
    • OKT3, delta chain antibody
    • OTTHUMP00000032544 antibody
    • T cell receptor antibody
    • T cell receptor T3 delta chain antibody
    • T cell receptor T3 gamma chain antibody
    • T cell receptor T3 zeta chain antibody
    • T cell receptor zeta chain antibody
    • T cell surface antigen T3/Leu 4 epsilon chain antibody
    • T cell surface glycoprotein CD3 antibody
    • T cell surface glycoprotein CD3 delta chain antibody
    • T cell surface glycoprotein CD3 epsilon chain antibody
    • T cell surface glycoprotein CD3 gamma chain antibody
    • T cell surface glycoprotein CD3 zeta chain antibody
    • T-cell antigen receptor complex, delta subunit of T3 antibody
    • T-cell antigen receptor complex, epsilon subunit of T3 antibody
    • T-cell antigen receptor complex, gamma subunit of T3 antibody
    • T-cell antigen receptor complex, zeta subunit of CD3 antibody
    • T-cell receptor T3 delta chain antibody
    • T-cell receptor T3 gamma chain antibody
    • T-cell surface antigen T3/Leu-4 epsilon chain antibody
    • T-cell surface glycoprotein CD3 delta chain antibody
    • T-cell surface glycoprotein CD3 epsilon chain antibody
    • T-cell surface glycoprotein CD3 gamma chain antibody
    • T3 antibody
    • T3d antibody
    • T3e antibody
    • T3g antibody
    • T3z antibody
    • TCRE antibody
    • TCRk antibody
    • Tcrz antibody
    • TCRzeta antibody
    see all

参考文献 (5)

ab22 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab22 は 5 報の論文で使用されています。

  • Zhang X  et al. miR-139-5p protects septic mice with acute lung injury by inhibiting Toll-like receptor 4/Myeloid differentiation factor 88/Nuclear factor-&mac_kgr;B signaling pathway. Clinics (Sao Paulo) 76:e2484 (2021). PubMed: 33681946
  • Zernickel E  et al. Targeting of BRM Sensitizes BRG1-Mutant Lung Cancer Cell Lines to Radiotherapy. Mol Cancer Ther 18:656-666 (2019). PubMed: 30478150
  • Stephen LA  et al. The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK. Dev Cell 47:122-132.e4 (2018). PubMed: 30220567
  • Spedicato M  et al. Experimental infection of rock pigeons (Columba livia) with three West Nile virus lineage 1 strains isolated in Italy between 2009 and 2012. Epidemiol Infect 144:1301-11 (2016). PubMed: 26493864
  • Beverley PC & Callard RE Distinctive functional characteristics of human "T" lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody. Eur J Immunol 11:329-34 (1981). PubMed: 6788570

レビューと Q&A

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1-4 of 4 Abreviews or Q&A

Question

I believe this antibody has been used for stimulation/proliferation assays of T cells or PBMCs. Can you tell me if this is so (we would coat wells with it along with CD28 to stimulate the lymphocytes)?

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Answer

Thank you for your enquiry regarding ab22. To our knowledge this antibody has only been tested in immunoprecipitation, radioimmunoassay, immunohistochemistry (Frozen sections)and FACS, we have no record of its use in cell proliferation assays. If you do come across a reference to this antibody in the literature we would be grateful to receive this information so we can update our datasheet to share this with future users. Please do not hesitate to contact us again if you need further information,

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Question

Does this abtibody can detect T cells from Human aortic aneurysm tissue (parafin sectioned)

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Answer

This antibody has not yet been tested on paraffin embedded sections. We are unable to advise whether it is suitable for use with Human aortic aneurysm tissue.

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Question

Can it be used to detect the rabbit T cells in aotic? Your earliest reply is much appreciated. thanks a lot!

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Answer

There should be no problem detecting T cells in the aorta. This antibody has been tested on human T cells, and not yet to our knowledge rabbit.

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Question

Does this antibody bind to rat CD 3 receptor?

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Answer

This antibody has not been tested for reactivity against the rat antigen.

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