Anti-CD3 抗体 [UCH-T1] (ab22)
Key features and details
- Mouse monoclonal [UCH-T1] to CD3
- Suitable for: Flow Cyt, IP, RIA, IHC-Fr
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-CD3 antibody [UCH-T1]
CD3 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [UCH-T1] to CD3 -
由来種
Mouse -
アプリケーション
適用あり: Flow Cyt, IP, RIA, IHC-Frmore details
適用なし: IHC-P -
種交差性
交差種: Human -
免疫原
Human infant thymocytes and Sezary cells
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エピトープ
Epsilon-chain -
特記事項
Use: Enrichment of T cell populations by cell sorting or panning.Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
UCH-T1 -
ミエローマ
P3-NS1/1-Ag4-1 -
アイソタイプ
IgG1 -
軽鎖の種類
kappa -
研究分野
関連製品
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Alternative Versions
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
Our Abpromise guarantee covers the use of ab22 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Flow Cyt | Use at an assay dependent concentration. ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
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| IP | Use at an assay dependent concentration. | |
| RIA | Use at an assay dependent concentration. | |
| IHC-Fr | Use at an assay dependent concentration. |
ターゲット情報
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機能
The CD3 complex mediates signal transduction. -
関連疾患
Defects in CD3D are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)/B(+)/NK(+) SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. -
配列類似性
Contains 1 ITAM domain. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 915 Human
- Entrez Gene: 916 Human
- Entrez Gene: 917 Human
- Entrez Gene: 919 Human
- Omim: 186740 Human
- Omim: 186780 Human
- Omim: 186790 Human
- Omim: 186830 Human
see all -
別名
- 4930549J05Rik antibody
- A430104F18Rik antibody
- AW552088 antibody
see all
プロトコール
データシートおよび資料
参考文献 (4)
ab22 は 4 報の論文で使用されています。
- Zernickel E et al. Targeting of BRM Sensitizes BRG1-Mutant Lung Cancer Cell Lines to Radiotherapy. Mol Cancer Ther 18:656-666 (2019). PubMed: 30478150
- Stephen LA et al. The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK. Dev Cell 47:122-132.e4 (2018). PubMed: 30220567
- Spedicato M et al. Experimental infection of rock pigeons (Columba livia) with three West Nile virus lineage 1 strains isolated in Italy between 2009 and 2012. Epidemiol Infect 144:1301-11 (2016). PubMed: 26493864
- Beverley PC & Callard RE Distinctive functional characteristics of human "T" lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody. Eur J Immunol 11:329-34 (1981). PubMed: 6788570
