Anti-CD3 抗体 [UCH-T1] (ab22)
Key features and details
- Mouse monoclonal [UCH-T1] to CD3
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-CD3 antibody [UCH-T1]
CD3 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [UCH-T1] to CD3 -
由来種
Mouse -
種交差性
交差種: Human -
免疫原
Human infant thymocytes and Sezary cells
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エピトープ
Epsilon-chain -
特記事項
Use: Enrichment of T cell populations by cell sorting or panning.The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
UCH-T1 -
ミエローマ
P3-NS1/1-Ag4-1 -
アイソタイプ
IgG1 -
軽鎖の種類
kappa -
研究分野
関連製品
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Alternative Versions
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Compatible Secondaries
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Isotype control
アプリケーション
追加情報
Is unsuitable for IHC-P.
ターゲット情報
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機能
The CD3 complex mediates signal transduction. -
関連疾患
Defects in CD3D are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)/B(+)/NK(+) SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. -
配列類似性
Contains 1 ITAM domain. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 915 Human
- Entrez Gene: 916 Human
- Entrez Gene: 917 Human
- Entrez Gene: 919 Human
- Omim: 186740 Human
- Omim: 186780 Human
- Omim: 186790 Human
- Omim: 186830 Human
see all -
別名
- 4930549J05Rik antibody
- A430104F18Rik antibody
- AW552088 antibody
see all
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab22 は 4 報の論文で使用されています。
- Zernickel E et al. Targeting of BRM Sensitizes BRG1-Mutant Lung Cancer Cell Lines to Radiotherapy. Mol Cancer Ther 18:656-666 (2019). PubMed: 30478150
- Stephen LA et al. The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK. Dev Cell 47:122-132.e4 (2018). PubMed: 30220567
- Spedicato M et al. Experimental infection of rock pigeons (Columba livia) with three West Nile virus lineage 1 strains isolated in Italy between 2009 and 2012. Epidemiol Infect 144:1301-11 (2016). PubMed: 26493864
- Beverley PC & Callard RE Distinctive functional characteristics of human "T" lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody. Eur J Immunol 11:329-34 (1981). PubMed: 6788570