Anti-CD19 抗体 [CB19] (ab1255)

Submit a review Q&A (1)References (4)

Key features and details

  • Mouse monoclonal [CB19] to CD19
  • Reacts with: Human
  • Isotype: IgG1

Conjugates logo Related conjugates and formulations

APC FITC PE

製品の概要

  • 製品名

    Anti-CD19 antibody [CB19]
    CD19 一次抗体 製品一覧

  • 製品の詳細

    Mouse monoclonal [CB19] to CD19

  • 由来種

    Mouse

  • 種交差性

    交差種: Human

  • 特記事項

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

製品の特性

アプリケーション

追加情報
Characterization of leukemias and lymphomas in human lysed whole peripheral blood or mononuclear cells separated by density gradient.

CD19 immunofluorescence analysis can be performed on a flow cytometerequipped with an excitation source of 488nm and fitted with logarithmic amplifiers.

10µl ofCD19 is sufficient for labelling of 1x106 cells.

ターゲット情報

  • 機能

    Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

  • 関連疾患

    Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) [MIM:613493]; also called antibody deficiency due to CD19 defect. CVID3 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.

  • 配列類似性

    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

  • 翻訳後修飾

    Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation.

  • 細胞内局在

    Membrane.
  • Information by UniProt

  • 参照データベース

    • 別名

      • Antibody deficiency due to defect in CD19 antibody
      • Antibody deficiency due to defect in CD19, included antibody
      • AW495831 antibody
      • B lymphocyte antigen CD19 antibody
      • B lymphocyte surface antigen B4 antibody
      • B-lymphocyte antigen CD19 antibody
      • B-lymphocyte surface antigen B4 antibody
      • B4 antibody
      • CD19 antibody
      • CD19 antigen antibody
      • CD19 molecule antibody
      • Cd19 protein antibody
      • CD19_HUMAN antibody
      • CVID3 antibody
      • Differentiation antigen CD19 antibody
      • Leu 12 antibody
      • Leu-12 antibody
      • Leu12 antibody
      • MGC109570 antibody
      • MGC12802 antibody
      • T-cell surface antigen Leu-12 antibody
      see all

    参考文献 (4)

    ab1255 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab1255 は 4 報の論文で使用されています。

    • Ruella M  et al. Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell. Nat Med 24:1499-1503 (2018). PubMed: 30275568
    • Silveira ELV  et al. Immune Cell Dynamics in Rhesus Macaques Infected with a Brazilian Strain of Zika Virus. J Immunol 199:1003-1011 (2017). PubMed: 28667164
    • Bradbury LE  et al. The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules. J Immunol 149:2841-50 (1992). PubMed: 1383329
    • Carter RH & Fearon DT CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Science 256:105-7 (1992). PubMed: 1373518

    レビューと Q&A

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    レビューを送る 質問を送る

    Question

    Does the Ab bind its target CD19 if the cells are fixed (for example with formaldehyde) prior to staining?


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    Answer

    I have had confirmation from the lab that cells may be fixed prior CD19 staining and acquisition.

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